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Literature DB >> 20958312

TAM receptors and the clearance of apoptotic cells.

Abstract

The Tyro3, Axl, and Mer (TAM) receptor tyrosine kinases and their ligands Gas6 and Protein S are required for the optimal phagocytosis of apoptotic cells in the mature immune, nervous, and reproductive systems. Genetic analyses in mice, rats, and humans reveal that this receptor-ligand system plays an especially important role in the phagocytosis that is triggered by the "eat-me" signal phosphatidylserine. Deficiencies in TAM signaling lead to human retinal dystrophies and may contribute to lupus and other human autoimmune diseases. The TAM system appears to interact and cooperate with several other phagocytic networks, including scavenger receptor and integrin-based systems, and may serve as a signaling hub that integrates these systems.

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Year: 2010 PMID： 20958312 PMCID： PMC3061224 DOI： 10.1111/j.1749-6632.2010.05744.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

50 in total

1. Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.

Authors: Q Lu; M Gore; Q Zhang; T Camenisch; S Boast; F Casagranda; C Lai; M K Skinner; R Klein; G K Matsushima; H S Earp; S P Goff; G Lemke
Journal: Nature Date: 1999-04-22 Impact factor: 49.962

2. Immunoexpression of Tyro 3 family receptors--Tyro 3, Axl, and Mer--and their ligand Gas6 in postnatal developing mouse testis.

Authors: Huizhen Wang; Yongmei Chen; Yehua Ge; Pengpeng Ma; Quanhong Ma; Jing Ma; Haikun Wang; Shepu Xue; Daishu Han
Journal: J Histochem Cytochem Date: 2005-06-13 Impact factor: 2.479

3. In vivo analysis of phagocytosis of apoptotic cells by testicular Sertoli cells.

Authors: Akihisa Nakagawa; Akiko Shiratsuchi; Kayoko Tsuda; Yoshinobu Nakanishi
Journal: Mol Reprod Dev Date: 2005-06 Impact factor: 2.609

4. Structural basis for Gas6-Axl signalling.

Authors: Takako Sasaki; Pjotr G Knyazev; Naomi J Clout; Yuri Cheburkin; Walter Göhring; Axel Ullrich; Rupert Timpl; Erhard Hohenester
Journal: EMBO J Date: 2005-12-15 Impact factor: 11.598

5. A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.

Authors: T D Camenisch; B H Koller; H S Earp; G K Matsushima
Journal: J Immunol Date: 1999-03-15 Impact factor: 5.422

6. Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells.

Authors: T Nakano; K Kawamoto; J Kishino; K Nomura; K Higashino; H Arita
Journal: Biochem J Date: 1997-04-15 Impact factor: 3.857

7. Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells.

Authors: Hideyuki Yoshida; Kohki Kawane; Masato Koike; Yoshimi Mori; Yasuo Uchiyama; Shigekazu Nagata
Journal: Nature Date: 2005-09-29 Impact factor: 49.962

8. TAM receptor function in the retinal pigment epithelium.

Authors: Dipti Prasad; Carla Vanina Rothlin; Patrick Burrola; Tal Burstyn-Cohen; Qingxian Lu; Pablo Garcia de Frutos; Greg Lemke
Journal: Mol Cell Neurosci Date: 2006-08-09 Impact factor: 4.314

9. The role of gamma-carboxylation in the anti-apoptotic function of gas6.

Authors: I Hasanbasic; I Rajotte; M Blostein
Journal: J Thromb Haemost Date: 2005-12 Impact factor: 5.824

10. A role for Mer tyrosine kinase in alphavbeta5 integrin-mediated phagocytosis of apoptotic cells.

Authors: Yi Wu; Sukhwinder Singh; Maria-Magdalena Georgescu; Raymond B Birge
Journal: J Cell Sci Date: 2005-02-01 Impact factor: 5.285

102 in total

Review 1. TAM receptor signaling and autoimmune disease.

Authors: Carla V Rothlin; Greg Lemke
Journal: Curr Opin Immunol Date: 2010-10-26 Impact factor: 7.486

2. The danger of sex and death in Scarf1(-/-) autoimmune mice.

Authors: David S Pisetsky
Journal: Nat Immunol Date: 2013-09 Impact factor: 25.606

3. Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors.

Authors: Suchita Bhattacharyya; Anna Zagórska; Erin D Lew; Bimmi Shrestha; Carla V Rothlin; John Naughton; Michael S Diamond; Greg Lemke; John A T Young
Journal: Cell Host Microbe Date: 2013-08-14 Impact factor: 21.023

Review 4. Biology of the TAM receptors.

Authors: Greg Lemke
Journal: Cold Spring Harb Perspect Biol Date: 2013-11-01 Impact factor: 10.005

5. GAS6 is a key homeostatic immunological regulator of host-commensal interactions in the oral mucosa.

Authors: Maria Nassar; Yaara Tabib; Tal Capucha; Gabriel Mizraji; Tsipora Nir; Meirav Pevsner-Fischer; Gili Zilberman-Schapira; Oded Heyman; Gabriel Nussbaum; Herve Bercovier; Asaf Wilensky; Eran Elinav; Tal Burstyn-Cohen; Avi-Hai Hovav
Journal: Proc Natl Acad Sci U S A Date: 2017-01-03 Impact factor: 11.205

10. Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2.

Authors: V A Tyurin; K Balasubramanian; D Winnica; Y Y Tyurina; A S Vikulina; R R He; A A Kapralov; C H Macphee; V E Kagan
Journal: Cell Death Differ Date: 2014-01-24 Impact factor: 15.828