BACKGROUND: Ductal carcinoma in situ (DCIS) is associated with low rates of mortality. Outcomes are generally assessed in terms of recurrence. METHODS: Published studies were abstracted from MEDLINE and other sources. We include articles published through January 31, 2009; 10 publications of five randomized controlled trials and 133 publications of 64 observational studies were reviewed. RESULTS: Whole-breast radiation therapy following breast-conserving surgery (BCS) was consistently associated with a reduced incidence of local DCIS recurrence and local invasive carcinoma. Women undergoing mastectomy were less likely than women undergoing lumpectomy with or without radiation to experience local DCIS or invasive recurrence. Tamoxifen use reduced risk of recurrent DCIS or invasive carcinoma. CONCLUSIONS: BCS plus radiation and mastectomy appear to yield equivalent outcomes, whereas BCS alone tends to be inferior to mastectomy. Tamoxifen seems helpful in treating DCIS.
BACKGROUND:Ductal carcinoma in situ (DCIS) is associated with low rates of mortality. Outcomes are generally assessed in terms of recurrence. METHODS: Published studies were abstracted from MEDLINE and other sources. We include articles published through January 31, 2009; 10 publications of five randomized controlled trials and 133 publications of 64 observational studies were reviewed. RESULTS: Whole-breast radiation therapy following breast-conserving surgery (BCS) was consistently associated with a reduced incidence of local DCIS recurrence and local invasive carcinoma. Women undergoing mastectomy were less likely than women undergoing lumpectomy with or without radiation to experience local DCIS or invasive recurrence. Tamoxifen use reduced risk of recurrent DCIS or invasive carcinoma. CONCLUSIONS: BCS plus radiation and mastectomy appear to yield equivalent outcomes, whereas BCS alone tends to be inferior to mastectomy. Tamoxifen seems helpful in treating DCIS.
Authors: Pamela R Benitez; Oscar Streeter; Frank Vicini; Vivek Mehta; Coral Quiet; Robert Kuske; Mary Katherine Hayes; Doug Arthur; Henry Kuerer; Gary Freedman; Martin Keisch; Thomas Dipetrillo; David Khan; Richard Hudes Journal: Am J Surg Date: 2006-10 Impact factor: 2.565
Authors: M Clarke; R Collins; S Darby; C Davies; P Elphinstone; V Evans; J Godwin; R Gray; C Hicks; S James; E MacKinnon; P McGale; T McHugh; R Peto; C Taylor; Y Wang Journal: Lancet Date: 2005-12-17 Impact factor: 79.321
Authors: Nina Bijker; Philip Meijnen; Johannes L Peterse; Jan Bogaerts; Irène Van Hoorebeeck; Jean-Pierre Julien; Massimiliano Gennaro; Philippe Rouanet; Antoine Avril; Ian S Fentiman; Harry Bartelink; Emiel J Th Rutgers Journal: J Clin Oncol Date: 2006-06-26 Impact factor: 44.544
Authors: N Bijker; J L Peterse; L Duchateau; J P Julien; I S Fentiman; C Duval; S Di Palma; J Simony-Lafontaine; I de Mascarel; M J van de Vijver Journal: J Clin Oncol Date: 2001-04-15 Impact factor: 44.544
Authors: Joan L Warren; Donald L Weaver; Therese Bocklage; Charles R Key; Charles E Platz; Kathleen A Cronin; Rachel Ballard-Barbash; Shawna C Willey; Linda C Harlan Journal: Cancer Date: 2005-11-01 Impact factor: 6.860
Authors: Jacqueline S Jeruss; Frank A Vicini; Peter D Beitsch; Bruce G Haffty; Coral A Quiet; Victor J Zannis; Angela J Keleher; Delia M Garcia; Howard C Snider; Mark A Gittleman; Eric Whitacre; Pat W Whitworth; Richard E Fine; Stacey Arrambide; Henry M Kuerer Journal: Ann Surg Oncol Date: 2006-05-16 Impact factor: 5.344
Authors: Benjamin D Smith; Bruce G Haffty; Thomas A Buchholz; Grace L Smith; Deron H Galusha; Justin E Bekelman; Cary P Gross Journal: J Natl Cancer Inst Date: 2006-09-20 Impact factor: 13.506
Authors: Joan Houghton; W D George; Jack Cuzick; Catherine Duggan; Ian S Fentiman; Margaret Spittle Journal: Lancet Date: 2003-07-12 Impact factor: 79.321
Authors: D Craig Allred; Stewart J Anderson; Soonmyung Paik; D Lawrence Wickerham; Iris D Nagtegaal; Sandra M Swain; Elefetherios P Mamounas; Thomas B Julian; Charles E Geyer; Joseph P Costantino; Stephanie R Land; Norman Wolmark Journal: J Clin Oncol Date: 2012-03-05 Impact factor: 44.544
Authors: Mónica E López; Celia P Kaplan; Anna M Nápoles; Jennifer C Livaudais; E Shelley Hwang; Susan L Stewart; Joan Bloom; Leah Karliner Journal: J Cancer Surviv Date: 2013-02-14 Impact factor: 4.442
Authors: R Souchon; M-L Sautter-Bihl; F Sedlmayer; W Budach; J Dunst; P Feyer; R Fietkau; W Haase; W Harms; F Wenz; R Sauer Journal: Strahlenther Onkol Date: 2014-01 Impact factor: 3.621
Authors: Lawrence J Solin; Robert Gray; Frederick L Baehner; Steven M Butler; Lorie L Hughes; Carl Yoshizawa; Diana B Cherbavaz; Steven Shak; David L Page; George W Sledge; Nancy E Davidson; James N Ingle; Edith A Perez; William C Wood; Joseph A Sparano; Sunil Badve Journal: J Natl Cancer Inst Date: 2013-05-02 Impact factor: 13.506
Authors: D Generali; F M Buffa; S Deb; M Cummings; L E Reid; M Taylor; D Andreis; G Allevi; G Ferrero; D Byrne; M Martinotti; A Bottini; A L Harris; S R Lakhani; S B Fox Journal: Br J Cancer Date: 2014-05-29 Impact factor: 7.640
Authors: Fei Dong; Humayun Irshad; Eun-Yeong Oh; Melinda F Lerwill; Elena F Brachtel; Nicholas C Jones; Nicholas W Knoblauch; Laleh Montaser-Kouhsari; Nicole B Johnson; Luigi K F Rao; Beverly Faulkner-Jones; David C Wilbur; Stuart J Schnitt; Andrew H Beck Journal: PLoS One Date: 2014-12-09 Impact factor: 3.240
Authors: Lotte E Elshof; Michael Schaapveld; Marjanka K Schmidt; Emiel J Rutgers; Flora E van Leeuwen; Jelle Wesseling Journal: Breast Cancer Res Treat Date: 2016-09-08 Impact factor: 4.872