Literature DB >> 20954689

Structures of 2-acetylaminofluorene modified DNA revisited: insight into conformational heterogeneity.

Satyakam Patnaik1, Bongsup P Cho.   

Abstract

Despite the extensive data on dG-AAF, the major DNA adduct derived from the model carcinogen 2-acetylaminofluorene, little is known with respect to its solution structures. Here, we provide NMR/CD evidence for three conformers of dG-AAF in duplex DNA: major groove B-type (B), base-displaced stacked (S), and minor groove wedge (W). The S/B/W-conformational heterogeneities were found to be sensitive to the nature of the flanking DNA sequence contexts and pH.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20954689      PMCID： PMC2981646          DOI： 10.1021/tx100341u

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  17 in total

1.  pH and cation effects on the properties of parallel pyrimidine motif DNA triplexes.

Authors:  N Sugimoto; P Wu; H Hara; Y Kawamoto
Journal:  Biochemistry       Date:  2001-08-07       Impact factor: 3.162

2.  NMR and computational characterization of the N-(deoxyguanosin-8-yl)aminofluorene adduct [(AF)G] opposite adenosine in DNA: (AF)G[syn].A[anti] pair formation and its pH dependence.

Authors:  D Norman; P Abuaf; B E Hingerty; D Live; D Grunberger; S Broyde; D J Patel
Journal:  Biochemistry       Date:  1989-09-05       Impact factor: 3.162

3.  Formation and persistence of DNA adducts during and after a long-term administration of 2-nitrofluorene.

Authors:  X S Cui; L C Eriksson; L Möller
Journal:  Mutat Res       Date:  1999-06-07       Impact factor: 2.433

4.  Influence of flanking sequence context on the mutagenicity of acetylaminofluorene-derived DNA adducts in mammalian cells.

Authors:  S Shibutani; N Suzuki; X Tan; F Johnson; A P Grollman
Journal:  Biochemistry       Date:  2001-03-27       Impact factor: 3.162

5.  Recognition and incision of site-specifically modified C8 guanine adducts formed by 2-aminofluorene, N-acetyl-2-aminofluorene and 1-nitropyrene by UvrABC nuclease.

Authors:  C Luo; R Krishnasamy; A K Basu; Y Zou
Journal:  Nucleic Acids Res       Date:  2000-10-01       Impact factor: 16.971

6.  Human and E.coli excinucleases are affected differently by the sequence context of acetylaminofluorene-guanine adduct.

Authors:  D Mu; E Bertrand-Burggraf; J C Huang; R P Fuchs; A Sancar; B P Fuchs
Journal:  Nucleic Acids Res       Date:  1994-11-25       Impact factor: 16.971

7.  Structural characterization of an N-acetyl-2-aminofluorene (AAF) modified DNA oligomer by NMR, energy minimization, and molecular dynamics.

Authors:  S F O'Handley; D G Sanford; R Xu; C C Lester; B E Hingerty; S Broyde; T R Krugh
Journal:  Biochemistry       Date:  1993-03-16       Impact factor: 3.162

8.  Minor-groove binding models for acetylaminofluorene modified DNA.

Authors:  R Shapiro; B E Hingerty; S Broyde
Journal:  J Biomol Struct Dyn       Date:  1989-12

Review 9.  Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites.

Authors:  R H Heflich; R E Neft
Journal:  Mutat Res       Date:  1994-10       Impact factor: 2.433

10.  Influence of flanking sequence context on the conformational flexibility of aminofluorene-modified dG adduct in dA mismatch DNA duplexes.

Authors:  Nidhi Jain; Srinivasarao Meneni; Vipin Jain; Bongsup P Cho
Journal:  Nucleic Acids Res       Date:  2009-01-16       Impact factor: 16.971
View more
  15 in total

1.  Effect of base sequence context on the conformational heterogeneity of aristolactam-I adducted DNA: structural and energetic insights into sequence-dependent repair and mutagenicity.

Authors:  Preetleen Kathuria; Purshotam Sharma; Stacey D Wetmore
Journal:  Toxicol Res (Camb)       Date:  2015-10-23       Impact factor: 3.524

Review 2.  A Comprehensive View of Translesion Synthesis in Escherichia coli.

Authors:  Shingo Fujii; Robert P Fuchs
Journal:  Microbiol Mol Biol Rev       Date:  2020-06-17       Impact factor: 11.056

3.  Insights into the conformation of aminofluorene-deoxyguanine adduct in a DNA polymerase active site.

Authors:  Vaidyanathan G Vaidyanathan; Fengting Liang; William A Beard; David D Shock; Samuel H Wilson; Bongsup P Cho
Journal:  J Biol Chem       Date:  2013-06-24       Impact factor: 5.157

4.  Conformational Insights into the Mechanism of Acetylaminofluorene-dG-Induced Frameshift Mutations in the NarI Mutational Hotspot.

Authors:  Lifang Xu; Bongsup P Cho
Journal:  Chem Res Toxicol       Date:  2016-01-15       Impact factor: 3.739

5.  Structure and thermodynamic insights on acetylaminofluorene-modified deletion DNA duplexes as models for frameshift mutagenesis.

Authors:  Anusha Sandineni; Bin Lin; Alexander D MacKerell; Bongsup P Cho
Journal:  Chem Res Toxicol       Date:  2013-06-04       Impact factor: 3.739

6.  Structural and thermodynamic insight into Escherichia coli UvrABC-mediated incision of cluster diacetylaminofluorene adducts on the NarI sequence.

Authors:  Vipin Jain; Benjamin Hilton; Bin Lin; Anshu Jain; Alexander D MacKerell; Yue Zou; Bongsup P Cho
Journal:  Chem Res Toxicol       Date:  2013-07-25       Impact factor: 3.739

7.  Conformational and thermodynamic properties modulate the nucleotide excision repair of 2-aminofluorene and 2-acetylaminofluorene dG adducts in the NarI sequence.

Authors:  Vipin Jain; Benjamin Hilton; Satyakam Patnaik; Yue Zou; M Paul Chiarelli; Bongsup P Cho
Journal:  Nucleic Acids Res       Date:  2012-01-12       Impact factor: 16.971

8.  Nucleotide excision repair of 2-acetylaminofluorene- and 2-aminofluorene-(C8)-guanine adducts: molecular dynamics simulations elucidate how lesion structure and base sequence context impact repair efficiencies.

Authors:  Hong Mu; Konstantin Kropachev; Lihua Wang; Lu Zhang; Alexander Kolbanovskiy; Marina Kolbanovskiy; Nicholas E Geacintov; Suse Broyde
Journal:  Nucleic Acids Res       Date:  2012-08-16       Impact factor: 16.971

9.  Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor.

Authors:  Vipin Jain; Benjamin Hilton; Bin Lin; Satyakam Patnaik; Fengting Liang; Eva Darian; Yue Zou; Alexander D Mackerell; Bongsup P Cho
Journal:  Nucleic Acids Res       Date:  2012-11-23       Impact factor: 16.971

10.  Conformational insights into the lesion and sequence effects for arylamine-induced translesion DNA synthesis: 19F NMR, surface plasmon resonance, and primer kinetic studies.

Authors:  Vipin Jain; Vaidyanathan G Vaidyanathan; Satyakam Patnaik; Sathyaraj Gopal; Bongsup P Cho
Journal:  Biochemistry       Date:  2014-06-10       Impact factor: 3.162
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.