Literature DB >> 20953352

Reelin Signaling, Hippocampal Neurogenesis, and Efficacy of Aspirin Intake & Stem Cell Transplantation in Aging and Alzheimer's disease.

Ashok K Shetty1.   

Abstract

Comprehending the mechanisms underlying the pathophysiology of aging and Alzheimer's disease has immense value for developing strategies that promote successful aging and prevent or cure Alzheimer's disease. The first issue of the new journal, "Aging & Disease" comprises articles that discuss the current knowledge pertaining to changes in reelin signaling in normal & pathological forms of aging, memory and neurogenesis in Aging & Alzheimer's disease, the efficacy of a non-steroidal anti-inflammatory drug aspirin in combination with docosahexaenoic acid for reducing the risk for Alzheimer's disease, and the usefulness of stem cell transplantation for improving memory in aging and Alzheimer's disease. The highlights and the importance of the above issues to Aging and Alzheimer's disease are discussed in this commentary.

Entities:  

Year:  2010        PMID： 20953352      PMCID： PMC2953809     

Source DB:  PubMed          Journal:  Aging Dis        ISSN： 2152-5250            Impact factor:   6.745


  105 in total

1.  Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus.

Authors:  Christoph Schmidt-Hieber; Peter Jonas; Josef Bischofberger
Journal:  Nature       Date:  2004-04-25       Impact factor: 49.962

2.  Exercise enhances learning and hippocampal neurogenesis in aged mice.

Authors:  Henriette van Praag; Tiffany Shubert; Chunmei Zhao; Fred H Gage
Journal:  J Neurosci       Date:  2005-09-21       Impact factor: 6.167

3.  Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib.

Authors:  Barbara K Martin; Christine Szekely; Jason Brandt; Steven Piantadosi; John C S Breitner; Suzanne Craft; Denis Evans; Robert Green; Michael Mullan
Journal:  Arch Neurol       Date:  2008-05-12

4.  Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: role of astrocytes.

Authors:  Ashok K Shetty; Bharathi Hattiangady; Geetha A Shetty
Journal:  Glia       Date:  2005-08-15       Impact factor: 7.452

5.  Proliferation of progenitor cells in the adult rat brain correlates with the presence of vimentin-expressing astrocytes.

Authors:  G Alonso
Journal:  Glia       Date:  2001-06       Impact factor: 7.452

6.  Neural stem cells improve memory in an inducible mouse model of neuronal loss.

Authors:  Tritia R Yamasaki; Mathew Blurton-Jones; Debbi A Morrissette; Masashi Kitazawa; Salvatore Oddo; Frank M LaFerla
Journal:  J Neurosci       Date:  2007-10-31       Impact factor: 6.167

7.  Hippocampal neurotrophin levels after injury: Relationship to the age of the hippocampus at the time of injury.

Authors:  Ashok K Shetty; Muddanna S Rao; Bharathi Hattiangady; Vandana Zaman; Geetha A Shetty
Journal:  J Neurosci Res       Date:  2004-11-15       Impact factor: 4.164

8.  Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial.

Authors:  C G Lyketsos; J C S Breitner; R C Green; B K Martin; C Meinert; S Piantadosi; M Sabbagh
Journal:  Neurology       Date:  2007-04-25       Impact factor: 9.910

9.  Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation.

Authors:  Vivi M Heine; Suharti Maslam; Marian Joëls; Paul J Lucassen
Journal:  Neurobiol Aging       Date:  2004-03       Impact factor: 4.673

10.  Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression.

Authors:  Victor L Marcheselli; Song Hong; Walter J Lukiw; Xiao Hua Tian; Karsten Gronert; Alberto Musto; Mattie Hardy; Juan M Gimenez; Nan Chiang; Charles N Serhan; Nicolas G Bazan
Journal:  J Biol Chem       Date:  2003-08-15       Impact factor: 5.157
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  3 in total

1.  Age-Induced Alterations in Hippocampal Function and Metabolism.

Authors:  Pavan K Shetty; Francesca Galeffi; Dennis A Turner
Journal:  Aging Dis       Date:  2011-06       Impact factor: 6.745

2.  Intracerebral Transplantation of Neural Stem Cells Restores Manganese-Induced Cognitive Deficits in Mice.

Authors:  Huijuan Shu; Zhongxin Guo; Xiangren Chen; Shuya Qi; Xinxin Xiong; Shuang Xia; Qingyun Huang; Ling Lan; Jiangu Gong; Shaoming Huang; Boning Yang; Guohe Tan
Journal:  Aging Dis       Date:  2021-04-01       Impact factor: 6.745

3.  Characterization of hippocampal Cajal-Retzius cells during development in a mouse model of Alzheimer's disease (Tg2576).

Authors:  Dongming Yu; Wenjuan Fan; Ping Wu; Jiexin Deng; Jing Liu; Yanli Niu; Mingshan Li; Jinbo Deng
Journal:  Neural Regen Res       Date:  2014-02-15       Impact factor: 5.135
  3 in total

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