Literature DB >> 20953196

N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release.

Alexander M Weber1, Fiona K Wong, Adele R Tufford, Lyanne C Schlichter, Victor Matveev, Elise F Stanley.   

Abstract

Presynaptic terminals favor intermediate-conductance Ca(V)2.2 (N type) over high-conductance Ca(V)1 (L type) channels for single-channel, Ca(2+) nanodomain-triggered synaptic vesicle fusion. However, the standard Ca(V)1>Ca(V)2>Ca(V)3 conductance hierarchy is based on recordings using nonphysiological divalent ion concentrations. We found that, with physiological Ca(2+) gradients, the hierarchy was Ca(V)2.2>Ca(V)1>Ca(V)3. Mathematical modeling predicts that the Ca(V)2.2 Ca(2+) nanodomain, which is ∼25% more extensive than that generated by Ca(V)1, can activate a calcium-fusion sensor located on the proximal face of the synaptic vesicle.

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Year:  2010        PMID： 20953196     DOI： 10.1038/nn.2657

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  14 in total

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2.  Ca2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction.

Authors:  Vahid Shahrezaei; Alex Cao; Kerry R Delaney
Journal:  J Neurosci       Date:  2006-12-20       Impact factor: 6.167

3.  The presynaptic CaV2.2 channel-transmitter release site core complex.

Authors:  Rajesh Khanna; Qi Li; Joerg Bewersdorf; Elise F Stanley
Journal:  Eur J Neurosci       Date:  2007-08       Impact factor: 3.386

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Authors:  Iancu Bucurenciu; Josef Bischofberger; Peter Jonas
Journal:  Nat Neurosci       Date:  2009-12-13       Impact factor: 24.884

5.  Single L-type calcium channel conductance with physiological levels of calcium in chick ciliary ganglion neurons.

Authors:  P J Church; E F Stanley
Journal:  J Physiol       Date:  1996-10-01       Impact factor: 5.182

Review 6.  The calcium channel and the organization of the presynaptic transmitter release face.

Authors:  E F Stanley
Journal:  Trends Neurosci       Date:  1997-09       Impact factor: 13.837

7.  A unified model of presynaptic release site gating by calcium channel domains.

Authors:  Luigi Gentile; Elise F Stanley
Journal:  Eur J Neurosci       Date:  2005-01       Impact factor: 3.386

8.  Transmission by presynaptic spike-like depolarization in the squid giant synapse.

Authors:  R Llinás; M Sugimori; S M Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

9.  Single calcium channels and acetylcholine release at a presynaptic nerve terminal.

Authors:  E F Stanley
Journal:  Neuron       Date:  1993-12       Impact factor: 17.173

10.  Spatial Distribution of Calcium Entry Evoked by Single Action Potentials within the Presynaptic Active Zone.

Authors:  Elliot S Wachman; Robert E Poage; Joel R Stiles; Daniel L Farkas; Stephen D Meriney
Journal:  J Neurosci       Date:  2004-03-24       Impact factor: 6.167
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  59 in total

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Journal:  J Biol Chem       Date:  2011-11-30       Impact factor: 5.157

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3.  A mathematical model of the tripartite synapse: astrocyte-induced synaptic plasticity.

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4.  Comparison of Ca2+ transients and [Ca2+]i in the dendrites and boutons of non-fast-spiking GABAergic hippocampal interneurons using two-photon laser microscopy and high- and low-affinity dyes.

Authors:  Máté Kisfali; Tibor Lrincz; E Sylvester Vizi
Journal:  J Physiol       Date:  2013-08-27       Impact factor: 5.182

5.  Ca2+ channel nanodomains boost local Ca2+ amplitude.

Authors:  Michael R Tadross; Richard W Tsien; David T Yue
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-09       Impact factor: 11.205

6.  Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.

Authors:  Norbert Weiss; Alejandro Sandoval; Shigeki Kyonaka; Ricardo Felix; Yasuo Mori; Michel De Waard
Journal:  Pflugers Arch       Date:  2011-02-18       Impact factor: 3.657

7.  Modeling a Ca(2+) channel/BKCa channel complex at the single-complex level.

Authors:  Daniel H Cox
Journal:  Biophys J       Date:  2014-12-16       Impact factor: 4.033

8.  Acute dissociation of lamprey reticulospinal axons to enable recording from the release face membrane of individual functional presynaptic terminals.

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Journal:  J Vis Exp       Date:  2014-10-01       Impact factor: 1.355

9.  PresyNaptic calcium channels: why is P selected before N?

Authors:  Elise F Stanley
Journal:  Biophys J       Date:  2015-02-03       Impact factor: 4.033

10.  C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins.

Authors:  Mitsuru Hirano; Yoshinori Takada; Chee Fah Wong; Kazuma Yamaguchi; Hiroshi Kotani; Tatsuki Kurokawa; Masayuki X Mori; Terrance P Snutch; Michel Ronjat; Michel De Waard; Yasuo Mori
Journal:  J Biol Chem       Date:  2017-04-04       Impact factor: 5.157
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