Literature DB >> 20010820

A small number of open Ca2+ channels trigger transmitter release at a central GABAergic synapse.

Iancu Bucurenciu1, Josef Bischofberger, Peter Jonas.   

Abstract

To determine the number of open Ca(2+) channels necessary for transmitter release at the inhibitory basket cell-granule cell synapse in rat hippocampus, we combined presynaptic Ca(2+) imaging, recording of postsynaptic currents and modeling. We found that that the opening of three or fewer Ca(2+) channels triggered transmitter release. Furthermore, a small number of Ca(2+) channels were able to evoke release with high temporal precision, despite stochastic Ca(2+) channel opening.

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Year:  2009        PMID： 20010820     DOI： 10.1038/nn.2461

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  15 in total

Review 1.  Usefulness and limitations of linear approximations to the understanding of Ca++ signals.

Authors:  E Neher
Journal:  Cell Calcium       Date:  1998 Nov-Dec       Impact factor: 6.817

2.  Developmental transformation of the release modality at the calyx of Held synapse.

Authors:  Michael J Fedchyshyn; Lu-Yang Wang
Journal:  J Neurosci       Date:  2005-04-20       Impact factor: 6.167

Review 3.  The calcium signal for transmitter secretion from presynaptic nerve terminals.

Authors:  G J Augustine; E M Adler; M P Charlton
Journal:  Ann N Y Acad Sci       Date:  1991       Impact factor: 5.691

4.  Ca2+ from one or two channels controls fusion of a single vesicle at the frog neuromuscular junction.

Authors:  Vahid Shahrezaei; Alex Cao; Kerry R Delaney
Journal:  J Neurosci       Date:  2006-12-20       Impact factor: 6.167

5.  Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons.

Authors:  Liyi Li; Josef Bischofberger; Peter Jonas
Journal:  J Neurosci       Date:  2007-12-05       Impact factor: 6.167

6.  Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse.

Authors:  Iancu Bucurenciu; Akos Kulik; Beat Schwaller; Michael Frotscher; Peter Jonas
Journal:  Neuron       Date:  2008-02-28       Impact factor: 17.173

7.  Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses.

Authors:  L G Wu; R E Westenbroek; J G Borst; W A Catterall; B Sakmann
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

Review 8.  The calcium channel and the organization of the presynaptic transmitter release face.

Authors:  E F Stanley
Journal:  Trends Neurosci       Date:  1997-09       Impact factor: 13.837

Review 9.  Short-term synaptic plasticity.

Authors:  Robert S Zucker; Wade G Regehr
Journal:  Annu Rev Physiol       Date:  2002       Impact factor: 19.318

10.  Calcium control of transmitter release at a cerebellar synapse.

Authors:  I M Mintz; B L Sabatini; W G Regehr
Journal:  Neuron       Date:  1995-09       Impact factor: 17.173
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  70 in total

1.  Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from stores.

Authors:  Ai-Hui Tang; Miranda A Karson; Daniel A Nagode; J Michael McIntosh; Victor N Uebele; John J Renger; Matthias Klugmann; Teresa A Milner; Bradley E Alger
Journal:  J Neurosci       Date:  2011-09-21       Impact factor: 6.167

2.  Heterogeneity and independency of unitary synaptic outputs from hippocampal CA3 pyramidal cells.

Authors:  Takuya Sasaki; Norio Matsuki; Yuji Ikegaya
Journal:  J Physiol       Date:  2012-06-25       Impact factor: 5.182

3.  N-type Ca2+ channels carry the largest current: implications for nanodomains and transmitter release.

Authors:  Alexander M Weber; Fiona K Wong; Adele R Tufford; Lyanne C Schlichter; Victor Matveev; Elise F Stanley
Journal:  Nat Neurosci       Date:  2010-10-17       Impact factor: 24.884

4.  Atypical properties of release and short-term depression at a specialized nicotinic synapse in the Mauthner cell network.

Authors:  Simon Gelman; Charlotte L Grove; Donald S Faber
Journal:  J Exp Biol       Date:  2011-05-01       Impact factor: 3.312

5.  An excess-calcium-binding-site model predicts neurotransmitter release at the neuromuscular junction.

Authors:  Markus Dittrich; John M Pattillo; J Darwin King; Soyoun Cho; Joel R Stiles; Stephen D Meriney
Journal:  Biophys J       Date:  2013-06-18       Impact factor: 4.033

6.  Comparison of Ca2+ transients and [Ca2+]i in the dendrites and boutons of non-fast-spiking GABAergic hippocampal interneurons using two-photon laser microscopy and high- and low-affinity dyes.

Authors:  Máté Kisfali; Tibor Lrincz; E Sylvester Vizi
Journal:  J Physiol       Date:  2013-08-27       Impact factor: 5.182

7.  Single-pixel optical fluctuation analysis of calcium channel function in active zones of motor nerve terminals.

Authors:  Fujun Luo; Markus Dittrich; Joel R Stiles; Stephen D Meriney
Journal:  J Neurosci       Date:  2011-08-03       Impact factor: 6.167

Review 8.  From the stochasticity of molecular processes to the variability of synaptic transmission.

Authors:  Claire Ribrault; Ken Sekimoto; Antoine Triller
Journal:  Nat Rev Neurosci       Date:  2011-06-20       Impact factor: 34.870

9.  Release from the cone ribbon synapse under bright light conditions can be controlled by the opening of only a few Ca(2+) channels.

Authors:  Theodore M Bartoletti; Skyler L Jackman; Norbert Babai; Aaron J Mercer; Richard H Kramer; Wallace B Thoreson
Journal:  J Neurophysiol       Date:  2011-08-31       Impact factor: 2.714

10.  Transmitter release is evoked with low probability predominately by calcium flux through single channel openings at the frog neuromuscular junction.

Authors:  Fujun Luo; Markus Dittrich; Soyoun Cho; Joel R Stiles; Stephen D Meriney
Journal:  J Neurophysiol       Date:  2015-02-04       Impact factor: 2.714
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