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Literature DB >> 20951145

A prospective on drug abuse-associated epigenetics and HIV-1 replication.

Abstract

Drugs of abuse serve as cofactors to susceptibility to HIV infection and disease progression. Although clinical reports indicate association between HIV/AIDS and drug use, the molecular mechanism of infection susceptibility and disease progression remains unclear. Drugs such as cocaine exert their addictive effects in part by epigenetic mechanisms. Given that epigenetic modifications play an important role in HIV-1 life cycle, it is essential to unravel whether drug abuse-associated epigenetic changes may contribute to HIV/AIDS. In this article we will provide a prospective on the impact of epigenetic mechanisms on HIV-1 life cycle.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20951145 PMCID： PMC3046297 DOI： 10.1016/j.lfs.2010.10.005

Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037

63 in total

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Authors: D Pruss; F D Bushman; A P Wolffe
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A prospective on drug abuse-associated epigenetics and HIV-1 replication.

1. HIV integration site selection: targeting in macrophages and the effects of different routes of viral entry.

2. Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.

3. Association of maternal drug use during pregnancy with maternal HIV culture positivity and perinatal HIV transmission.

4. Drugs of abuse as possible co-factors in AIDS progression: summary of panel discussion.

5. Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.

6. Crack cocaine: effect modifier of RNA viral load and CD4 count in HIV infected African American women.

7. The human IL-13 locus in neonatal CD4+ T cells is refractory to the acquisition of a repressive chromatin architecture.

8. Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5.

9. Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core.

10. Selection of target sites for mobile DNA integration in the human genome.

Review 1. Epigenetics, drugs of abuse, and the retroviral promoter.

Review 2. Role of Autophagy in HIV Pathogenesis and Drug Abuse.

Review 3. Vitamin D receptor and epigenetics in HIV infection and drug abuse.

Review 4. Impact of cocaine abuse on HIV pathogenesis.

5. Epigenetic alterations in the brain associated with HIV-1 infection and methamphetamine dependence.