Literature DB >> 8016088

Human immunodeficiency virus integrase directs integration to sites of severe DNA distortion within the nucleosome core.

D Pruss1, F D Bushman, A P Wolffe.   

Abstract

We have examined the consequences of DNA distortion and specific histone-DNA contacts within the nucleosome for integration mediated by the human immunodeficiency virus (HIV)-encoded integrase enzyme. We find that sites of high-frequency integration cluster in the most severely deformed, kinked DNA regions within the nucleosome core. This may reflect either a preference for a wide major groove for association of the integrase or a requirement for target DNA distortion in the DNA strand transfer mechanism. Both the distortion and folding of the target DNA through packaging into nucleosomes may influence the selection of HIV integration sites within the chromosome.

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Year:  1994        PMID： 8016088      PMCID： PMC44107          DOI： 10.1073/pnas.91.13.5913

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Histone contributions to the structure of DNA in the nucleosome.

Authors:  J J Hayes; D J Clark; A P Wolffe
Journal:  Proc Natl Acad Sci U S A       Date:  1991-08-01       Impact factor: 11.205

2.  The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix.

Authors:  G Arents; R W Burlingame; B C Wang; W E Love; E N Moudrianakis
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

3.  Transcriptionally active genome regions are preferred targets for retrovirus integration.

Authors:  U Scherdin; K Rhodes; M Breindl
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

4.  Use of selectively trypsinized nucleosome core particles to analyze the role of the histone "tails" in the stabilization of the nucleosome.

Authors:  J Ausio; F Dong; K E van Holde
Journal:  J Mol Biol       Date:  1989-04-05       Impact factor: 5.469

5.  A positive role for histone acetylation in transcription factor access to nucleosomal DNA.

Authors:  D Y Lee; J J Hayes; D Pruss; A P Wolffe
Journal:  Cell       Date:  1993-01-15       Impact factor: 41.582

6.  Hotspots for unselected Ty1 transposition events on yeast chromosome III are near tRNA genes and LTR sequences.

Authors:  H Ji; D P Moore; M A Blomberg; L T Braiterman; D F Voytas; G Natsoulis; J D Boeke
Journal:  Cell       Date:  1993-06-04       Impact factor: 41.582

7.  Retroviral DNA integration directed by HIV integration protein in vitro.

Authors:  F D Bushman; T Fujiwara; R Craigie
Journal:  Science       Date:  1990-09-28       Impact factor: 47.728

8.  The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro.

Authors:  R Craigie; T Fujiwara; F Bushman
Journal:  Cell       Date:  1990-08-24       Impact factor: 41.582

9.  Retroviral integration sites in transgenic Mov mice frequently map in the vicinity of transcribed DNA regions.

Authors:  K Mooslehner; U Karls; K Harbers
Journal:  J Virol       Date:  1990-06       Impact factor: 5.103

10.  Simian virus 40 minichromosomes as targets for retroviral integration in vivo.

Authors:  P M Pryciak; H P Müller; H E Varmus
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205
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  116 in total

1.  Target DNA chromatinization modulates nicking by L1 endonuclease.

Authors:  G J Cost; A Golding; M S Schlissel; J D Boeke
Journal:  Nucleic Acids Res       Date:  2001-01-15       Impact factor: 16.971

2.  De novo evolution of satellite DNA on the rye B chromosome.

Authors:  T Langdon; C Seago; R N Jones; H Ougham; H Thomas; J W Forster; G Jenkins
Journal:  Genetics       Date:  2000-02       Impact factor: 4.562

3.  Targeted transposition by the V(D)J recombinase.

Authors:  Gregory S Lee; Matthew B Neiditch; Richard R Sinden; David B Roth
Journal:  Mol Cell Biol       Date:  2002-04       Impact factor: 4.272

4.  Isolation and analysis of retroviral integration targets by solo long terminal repeat inverse PCR.

Authors:  Yi Feng Jin; Toshio Ishibashi; Akio Nomoto; Michiaki Masuda
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

5.  Relationship between retroviral DNA integration and gene expression.

Authors:  J B Weidhaas; E L Angelichio; S Fenner; J M Coffin
Journal:  J Virol       Date:  2000-09       Impact factor: 5.103

6.  R2 retrotransposition on assembled nucleosomes depends on the translational position of the target site.

Authors:  Junqiang Ye; Zungyoon Yang; Jeffrey J Hayes; Thomas H Eickbush
Journal:  EMBO J       Date:  2002-12-16       Impact factor: 11.598

7.  The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.

Authors:  Manika P Bhadra; Nobuo Horikoshi; Sreerangam N C V L Pushpavallipvalli; Arpita Sarkar; Indira Bag; Anita Krishnan; John C Lucchesi; Rakesh Kumar; Qin Yang; Raj K Pandita; Mayank Singh; Utpal Bhadra; Joel C Eissenberg; Tej K Pandita
Journal:  Chromosoma       Date:  2011-11-10       Impact factor: 4.316

Review 8.  Integration by design.

Authors:  Suzanne Sandmeyer
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-05       Impact factor: 11.205

9.  Local definition of Ty1 target preference by long terminal repeats and clustered tRNA genes.

Authors:  Nurjana Bachman; Yolanda Eby; Jef D Boeke
Journal:  Genome Res       Date:  2004-06-14       Impact factor: 9.043

Review 10.  HIV DNA integration.

Authors:  Robert Craigie; Frederic D Bushman
Journal:  Cold Spring Harb Perspect Med       Date:  2012-07       Impact factor: 6.915
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