BACKGROUND AND PURPOSE: The pathophysiology of the presumed perihematomal edema immediately surrounding an acute intracerebral hemorrhage is poorly understood, and its composition may influence clinical outcome. Method-Twenty-three patients from the Diagnostic Accuracy of MRI in Spontaneous intracerebral Hemorrhage (DASH) study were prospectively enrolled and studied with MRI. Perfusion-weighted imaging, diffusion-weighted imaging, and fluid-attenuated inversion recovery sequences were coregistered. TMax (the time when the residue function reaches its maximum) and apparent diffusion coefficient values in the presumed perihematomal edema regions of interest were compared with contralateral mirror and remote ipsilateral hemispheric regions of interest. RESULTS: Compared with mirror and ipsilateral hemispheric regions of interest, TMax (the time when the residue function reaches its maximum) and apparent diffusion coefficient were consistently increased in the presumed perihematomal edema. Two thirds of the patients also exhibited patchy regions of restricted diffusion in the presumed perihematomal edema. CONCLUSIONS: The MRI profile of the presumed perihematomal edema in acute intracerebral hemorrhage exhibits delayed perfusion and increased diffusivity mixed with areas of reduced diffusion.
BACKGROUND AND PURPOSE: The pathophysiology of the presumed perihematomal edema immediately surrounding an acute intracerebral hemorrhage is poorly understood, and its composition may influence clinical outcome. Method-Twenty-three patients from the Diagnostic Accuracy of MRI in Spontaneous intracerebral Hemorrhage (DASH) study were prospectively enrolled and studied with MRI. Perfusion-weighted imaging, diffusion-weighted imaging, and fluid-attenuated inversion recovery sequences were coregistered. TMax (the time when the residue function reaches its maximum) and apparent diffusion coefficient values in the presumed perihematomal edema regions of interest were compared with contralateral mirror and remote ipsilateral hemispheric regions of interest. RESULTS: Compared with mirror and ipsilateral hemispheric regions of interest, TMax (the time when the residue function reaches its maximum) and apparent diffusion coefficient were consistently increased in the presumed perihematomal edema. Two thirds of the patients also exhibited patchy regions of restricted diffusion in the presumed perihematomal edema. CONCLUSIONS: The MRI profile of the presumed perihematomal edema in acute intracerebral hemorrhage exhibits delayed perfusion and increased diffusivity mixed with areas of reduced diffusion.
Authors: James M Gebel; Edward C Jauch; Thomas G Brott; Jane Khoury; Laura Sauerbeck; Shelia Salisbury; Judith Spilker; Thomas A Tomsick; John Duldner; Joseph P Broderick Journal: Stroke Date: 2002-11 Impact factor: 7.914
Authors: Ana M Pascual; Jose V López-Mut; Vicente Benlloch; Raquel Chamarro; Jose Soler; Miguel J A Láinez Journal: Cerebrovasc Dis Date: 2006-09-12 Impact factor: 2.762
Authors: C S Kidwell; J L Saver; J Mattiello; S Warach; D S Liebeskind; S Starkman; P M Vespa; J P Villablanca; N A Martin; J Frazee; J R Alger Journal: Neurology Date: 2001-11-13 Impact factor: 9.910
Authors: J Ricardo Carhuapoma; Peter B Barker; Daniel F Hanley; Paul Wang; Norman J Beauchamp Journal: AJNR Am J Neuroradiol Date: 2002-09 Impact factor: 3.825
Authors: Ken S Butcher; Tracey Baird; Lachlan MacGregor; Patricia Desmond; Brian Tress; Stephen Davis Journal: Stroke Date: 2004-06-03 Impact factor: 7.914
Authors: J-M Olivot; M Mlynash; G Zaharchuk; M Straka; R Bammer; N Schwartz; M G Lansberg; M E Moseley; G W Albers Journal: Neurology Date: 2009-03-31 Impact factor: 9.910
Authors: Peter D Schellinger; Jochen B Fiebach; Katrin Hoffmann; Kristina Becker; Berk Orakcioglu; Rainer Kollmar; Eric Jüttler; Peter Schramm; Stefan Schwab; Klaus Sartor; Werner Hacke Journal: Stroke Date: 2003-06-12 Impact factor: 7.914
Authors: Rexford D Newbould; Stefan T Skare; Thies H Jochimsen; Marcus T Alley; Michael E Moseley; Gregory W Albers; Roland Bammer Journal: Magn Reson Med Date: 2007-07 Impact factor: 3.737
Authors: Audrey Leasure; W Taylor Kimberly; Lauren H Sansing; Kristopher T Kahle; Golo Kronenberg; Hagen Kunte; J Marc Simard; Kevin N Sheth Journal: Curr Treat Options Neurol Date: 2016-02 Impact factor: 3.598
Authors: Mahesh P Kate; Mikkel B Hansen; Kim Mouridsen; Leif Østergaard; Victor Choi; Bronwen E Gould; Rebecca McCourt; Michael D Hill; Andrew M Demchuk; Shelagh B Coutts; Dariush Dowlatshahi; Derek J Emery; Brian H Buck; Kenneth S Butcher Journal: J Cereb Blood Flow Metab Date: 2013-09-18 Impact factor: 6.200