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Literature DB >> 20947363

Pharmacology of ionotropic glutamate receptors: A structural perspective.

Philipp Stawski¹, Harald Janovjak, Dirk Trauner.

Abstract

The impact of structural biology on the design of ligands (agonists, antagonists and modulators) for ionotropic glutamate receptors is reviewed.

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Year: 2010 PMID： 20947363 DOI： 10.1016/j.bmc.2010.09.012

Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641

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Cited

19 in total

Review 1. Emerging models of glutamate receptor ion channel structure and function.

Authors: Mark L Mayer
Journal: Structure Date: 2011-10-12 Impact factor: 5.006

Review 2. Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder.

Authors: Sunil Goodwani; Hannah Saternos; Fawaz Alasmari; Youssef Sari
Journal: Neurosci Biobehav Rev Date: 2017-02-24 Impact factor: 8.989

3. Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.

Authors: Lina Juknaitė; Yutaro Sugamata; Kazuya Tokiwa; Yuichi Ishikawa; Satoshi Takamizawa; Andrew Eng; Ryuichi Sakai; Darryl S Pickering; Karla Frydenvang; Geoffrey T Swanson; Jette S Kastrup; Masato Oikawa
Journal: J Med Chem Date: 2013-03-13 Impact factor: 7.446

4. Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.

Authors: Stefano Sainas; Piero Temperini; Jill C Farnsworth; Feng Yi; Stine Møllerud; Anders A Jensen; Birgitte Nielsen; Alice Passoni; Jette S Kastrup; Kasper B Hansen; Donatella Boschi; Darryl S Pickering; Rasmus P Clausen; Marco L Lolli
Journal: J Med Chem Date: 2019-04-18 Impact factor: 7.446

5. Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity.

Authors: T Masuoka; T Nakamura; M Kudo; J Yoshida; Y Takaoka; N Kato; T Ishibashi; N Imaizumi; M Nishio
Journal: Br J Pharmacol Date: 2014-12-15 Impact factor: 8.739

6. Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters.

Authors: Christian B M Poulie; Anna Alcaide; Mikkel Krell-Jørgensen; Younes Larsen; Eloi Astier; Walden E Bjørn-Yoshimoto; Feng Yi; Jed T Syrenne; Morten Storgaard; Birgitte Nielsen; Karla A Frydenvang; Anders A Jensen; Kasper B Hansen; Darryl S Pickering; Lennart Bunch
Journal: ACS Chem Neurosci Date: 2019-05-24 Impact factor: 4.418

Pharmacology of ionotropic glutamate receptors: A structural perspective.

Review 1. Emerging models of glutamate receptor ion channel structure and function.

Review 2. Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder.

3. Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.

4. Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.

5. Biphasic modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes to heat sensitivity.

6. Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters.

Review 7. Functional insights from glutamate receptor ion channel structures.

8. Potent anti-seizure effects of D-leucine.

9. Azo-propofols: photochromic potentiators of GABA(A) receptors.

Review 10. Sex differences in the glutamate system: Implications for addiction.