Literature DB >> 22968919

Azo-propofols: photochromic potentiators of GABA(A) receptors.

Marco Stein1, Simon J Middendorp, Valentina Carta, Ervin Pejo, Douglas E Raines, Stuart A Forman, Erwin Sigel, Dirk Trauner.   

Abstract

Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpoles.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 22968919      PMCID： PMC3606271          DOI： 10.1002/anie.201205475

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  24 in total

Review 1.  The Xenopus oocyte: system for the study of functional expression and modulation of proteins.

Authors:  Erwin Sigel; Frédéric Minier
Journal:  Mol Nutr Food Res       Date:  2005-03       Impact factor: 5.914

2.  Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors.

Authors:  Matthew Volgraf; Pau Gorostiza; Stephanie Szobota; Max R Helix; Ehud Y Isacoff; Dirk Trauner
Journal:  J Am Chem Soc       Date:  2007-01-17       Impact factor: 15.419

3.  Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor.

Authors:  Pau Gorostiza; Matthew Volgraf; Rika Numano; Stephanie Szobota; Dirk Trauner; Ehud Y Isacoff
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-19       Impact factor: 11.205

4.  Remote control of neuronal activity with a light-gated glutamate receptor.

Authors:  Stephanie Szobota; Pau Gorostiza; Filippo Del Bene; Claire Wyart; Doris L Fortin; Kathleen D Kolstad; Orapim Tulyathan; Matthew Volgraf; Rika Numano; Holly L Aaron; Ethan K Scott; Richard H Kramer; John Flannery; Herwig Baier; Dirk Trauner; Ehud Y Isacoff
Journal:  Neuron       Date:  2007-05-24       Impact factor: 17.173

5.  Photochemical control of endogenous ion channels and cellular excitability.

Authors:  Doris L Fortin; Matthew R Banghart; Timothy W Dunn; Katharine Borges; Daniel A Wagenaar; Quentin Gaudry; Movses H Karakossian; Thomas S Otis; William B Kristan; Dirk Trauner; Richard H Kramer
Journal:  Nat Methods       Date:  2008-03-02       Impact factor: 28.547

6.  Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR.

Authors:  Rika Numano; Stephanie Szobota; Albert Y Lau; Pau Gorostiza; Matthew Volgraf; Benoit Roux; Dirk Trauner; Ehud Y Isacoff
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-02       Impact factor: 11.205

7.  A factorial trial of six interventions for the prevention of postoperative nausea and vomiting.

Authors:  Christian C Apfel; Kari Korttila; Mona Abdalla; Heinz Kerger; Alparslan Turan; Ina Vedder; Carmen Zernak; Klaus Danner; Ritva Jokela; Stuart J Pocock; Stefan Trenkler; Markus Kredel; Andreas Biedler; Daniel I Sessler; Norbert Roewer
Journal:  N Engl J Med       Date:  2004-06-10       Impact factor: 91.245

Review 8.  International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update.

Authors:  Richard W Olsen; Werner Sieghart
Journal:  Pharmacol Rev       Date:  2008-09-12       Impact factor: 25.468

Review 9.  Propofol.

Authors:  C Vanlersberghe; F Camu
Journal:  Handb Exp Pharmacol       Date:  2008

10.  HCN1 channel subunits are a molecular substrate for hypnotic actions of ketamine.

Authors:  Xiangdong Chen; Shaofang Shu; Douglas A Bayliss
Journal:  J Neurosci       Date:  2009-01-21       Impact factor: 6.167
View more
  34 in total

1.  Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches.

Authors:  Alexandre Mourot; Christian Herold; Michael A Kienzler; Richard H Kramer
Journal:  Br J Pharmacol       Date:  2017-07-27       Impact factor: 8.739

2.  Optical control of antibacterial activity.

Authors:  Willem A Velema; Jan Pieter van der Berg; Mickel J Hansen; Wiktor Szymanski; Arnold J M Driessen; Ben L Feringa
Journal:  Nat Chem       Date:  2013-09-15       Impact factor: 24.427

3.  Reversible silencing of endogenous receptors in intact brain tissue using 2-photon pharmacology.

Authors:  Silvia Pittolo; Hyojung Lee; Anna Lladó; Sébastien Tosi; Miquel Bosch; Lídia Bardia; Xavier Gómez-Santacana; Amadeu Llebaria; Eduardo Soriano; Julien Colombelli; Kira E Poskanzer; Gertrudis Perea; Pau Gorostiza
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-13       Impact factor: 11.205

Review 4.  Synapses in the spotlight with synthetic optogenetics.

Authors:  Shai Berlin; Ehud Y Isacoff
Journal:  EMBO Rep       Date:  2017-04-10       Impact factor: 8.807

5.  Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

Authors:  C Zussy; X Gómez-Santacana; X Rovira; D De Bundel; S Ferrazzo; D Bosch; D Asede; F Malhaire; F Acher; J Giraldo; E Valjent; I Ehrlich; F Ferraguti; J-P Pin; A Llebaria; C Goudet
Journal:  Mol Psychiatry       Date:  2016-12-20       Impact factor: 15.992

Review 6.  Optochemical Control of Biological Processes in Cells and Animals.

Authors:  Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-01       Impact factor: 15.336

7.  An allosteric modulator to control endogenous G protein-coupled receptors with light.

Authors:  Silvia Pittolo; Xavier Gómez-Santacana; Kay Eckelt; Xavier Rovira; James Dalton; Cyril Goudet; Jean-Philippe Pin; Artur Llobet; Jesús Giraldo; Amadeu Llebaria; Pau Gorostiza
Journal:  Nat Chem Biol       Date:  2014-08-31       Impact factor: 15.040

Review 8.  Photochemical approaches to vision restoration.

Authors:  Russell N Van Gelder
Journal:  Vision Res       Date:  2015-02-11       Impact factor: 1.886

9.  Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells.

Authors:  Christian Hoppmann; Vanessa K Lacey; Gordon V Louie; Jing Wei; Joseph P Noel; Lei Wang
Journal:  Angew Chem Int Ed Engl       Date:  2014-03-11       Impact factor: 15.336

10.  Direct modulation of microtubule stability contributes to anthracene general anesthesia.

Authors:  Daniel J Emerson; Brian P Weiser; John Psonis; Zhengzheng Liao; Olena Taratula; Ashley Fiamengo; Xiaozhao Wang; Keizo Sugasawa; Amos B Smith; Roderic G Eckenhoff; Ivan J Dmochowski
Journal:  J Am Chem Soc       Date:  2013-03-29       Impact factor: 15.419
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.