| Literature DB >> 20946793 |
Lois Pollack1, Sebastian Doniach.
Abstract
Time-resolved small-angle X-ray scattering (SAXS) reports changes in the global conformation of macromolecules and is thus a valuable probe of structural transitions like RNA folding. Time-resolved SAXS has been applied to study folding of the Tetrahymena ribozyme. This chapter describes the methods that enable acquisition and analysis of time-resolved SAXS data and insights into RNA folding gained from these studies.Mesh:
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Year: 2009 PMID: 20946793 DOI: 10.1016/S0076-6879(09)69012-1
Source DB: PubMed Journal: Methods Enzymol ISSN: 0076-6879 Impact factor: 1.600