Literature DB >> 2094575

Genetic restriction of protective immunity to Plasmodium yoelii sporozoites.

W R Weiss1, M F Good, M R Hollingdale, L H Miller, J A Berzofsky.   

Abstract

Ten congenic strains of mice were immunized with irradiated sporozoites of Plasmodium yoelii. When challenged with viable sporozoites, only two strains had a high proportion of animals which did not develop blood-stage infections. Genes both within and outside the H-2 region affected the degree of protection. Immunity did not correlate with anti-sporozoite antibody levels. In vivo depletion of CD8+ T cells did not alter immunity in two of three congenic strains, implying the existence of a novel mechanism of cell-mediated immunity.

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Year:  1990        PMID： 2094575      PMCID： PMC2393051     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  11 in total

1.  CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.

Authors:  W R Weiss; M Sedegah; R L Beaudoin; L H Miller; M F Good
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

2.  Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites.

Authors:  L Schofield; J Villaquiran; A Ferreira; H Schellekens; R Nussenzweig; V Nussenzweig
Journal:  Nature       Date:  1987 Dec 17-23       Impact factor: 49.962

3.  Immunodominant protein epitopes. I. Induction of suppression to hen egg white lysozyme is obliterated by removal of the first three N-terminal amino acids.

Authors:  L S Wicker; M Katz; E E Sercarz; A Miller
Journal:  Eur J Immunol       Date:  1984-05       Impact factor: 5.532

4.  Immunoregulation in murine malaria. Susceptibility of inbred mice to infection with Plasmodium yoelii depends on the dynamic interplay of host and parasite genes.

Authors:  P C Sayles; D L Wassom
Journal:  J Immunol       Date:  1988-07-01       Impact factor: 5.422

5.  Expression of the natural resistance gene Lsh in resident liver macrophages.

Authors:  P R Crocker; J M Blackwell; D J Bradley
Journal:  Infect Immun       Date:  1984-03       Impact factor: 3.441

6.  Immune response gene regulation of immunity to Plasmodium berghei sporozoites and circumsporozoite protein vaccines. Overcoming genetic restriction with whole organism and subunit vaccines.

Authors:  S L Hoffman; J A Berzofsky; D Isenbarger; E Zeltser; W R Majarian; M Gross; W R Ballou
Journal:  J Immunol       Date:  1989-05-15       Impact factor: 5.422

7.  Cloned protein antigen-specific, Ia-restricted T cells with both helper and cytolytic activities: mechanisms of activation and killing.

Authors:  S Ozaki; J York-Jolley; H Kawamura; J A Berzofsky
Journal:  Cell Immunol       Date:  1987-04-01       Impact factor: 4.868

8.  Regulation of Leishmania populations within the host. II. genetic control of acute susceptibility of mice to Leishmania donovani infection.

Authors:  D J Bradley
Journal:  Clin Exp Immunol       Date:  1977-10       Impact factor: 4.330

9.  Synthetic peptide vaccine confers protection against murine malaria.

Authors:  F Zavala; J P Tam; P J Barr; P J Romero; V Ley; R S Nussenzweig; V Nussenzweig
Journal:  J Exp Med       Date:  1987-11-01       Impact factor: 14.307

10.  Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection.

Authors:  P Potocnjak; N Yoshida; R S Nussenzweig; V Nussenzweig
Journal:  J Exp Med       Date:  1980-06-01       Impact factor: 14.307
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  1 in total

Review 1.  Class I HLA-restricted cytotoxic T lymphocyte responses against malaria--elucidation on the basis of HLA peptide binding motifs.

Authors:  D L Doolan; B Wizel; S L Hoffman
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829
  1 in total

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