[Effect of amino acids on the beta-aspartokinase activity from Corynebacterium glutamicum of wild and mutant strains].

The effect of amino acids, their structural analogs and ammonium sulphate on the enzyme activity of beta-aspartokinase isolated from Corynebacterium glutamicum was studied. Two strains were used: one of the wild type and the other--a mutant strain whose growth remains uninhibited by a simultaneous addition of threonine and S-2-aminoethylcysteine, a lysine analog. Significant differences in the effect of amino acids and their analogs on the beta-aspartokinase activity of the parental and mutant strains were detected. These findings suggest that the lysine supersynthesis by the mutant strain of Corynebacterium glutamicum occurs due to genetically induced changes of allosteric properties of the mutant enzyme.