BACKGROUND & AIMS: We examined associations between the first-week energy and protein intake and clinical outcomes in medical ICU (MICU) patients who survived at least seven days. METHODS: We retrospectively studied 295 patients admitted to a 28-bed MICU between 2005 and 2007. High and low energy delivery (ED) and protein delivery (PD) were defined as having a mean daily intake relative to recommendation at ≥ 60% and <60%, respectively, during the 1st to 7th day of ICU stay. RESULTS: The high and low ED or PD groups did not differ with regard to length of ICU stay, length of hospital stay, or ventilator free time. Patients with low ED or low PD intake were at greater risk of mortality than their high intake counterparts (OR = 3.7 and 3.6; both p < 0.001). After adjusting for confounders, we found patients receiving low ED to be at 2.43 times the risk of ICU mortality than high ED (p = 0.020). Low PD was unrelated to ICU mortality. CONCLUSIONS: Patients receiving less than 60% of recommended energy intake during the first week of critical illness are at greater risk of mortality. There is a need for future randomized trials to investigate optimal energy delivery during critical illness.
BACKGROUND & AIMS: We examined associations between the first-week energy and protein intake and clinical outcomes in medical ICU (MICU) patients who survived at least seven days. METHODS: We retrospectively studied 295 patients admitted to a 28-bed MICU between 2005 and 2007. High and low energy delivery (ED) and protein delivery (PD) were defined as having a mean daily intake relative to recommendation at ≥ 60% and <60%, respectively, during the 1st to 7th day of ICU stay. RESULTS: The high and low ED or PD groups did not differ with regard to length of ICU stay, length of hospital stay, or ventilator free time. Patients with low ED or low PD intake were at greater risk of mortality than their high intake counterparts (OR = 3.7 and 3.6; both p < 0.001). After adjusting for confounders, we found patients receiving low ED to be at 2.43 times the risk of ICU mortality than high ED (p = 0.020). Low PD was unrelated to ICU mortality. CONCLUSIONS:Patients receiving less than 60% of recommended energy intake during the first week of critical illness are at greater risk of mortality. There is a need for future randomized trials to investigate optimal energy delivery during critical illness.
Authors: Ana Cláudia Thomaz; Carolline Ilha Silvério; Denise Johnsson Campos; Elena Emilia Moreira Kieuteka; Estela Iraci Rabito; Vaneuza Araújo Moreira Funke; Regina Maria Vilela Journal: Support Care Cancer Date: 2015-07-21 Impact factor: 3.603
Authors: G Elke; E Kuhnt; M Ragaller; D Schädler; I Frerichs; F M Brunkhorst; M Löffler; K Reinhart; N Weiler Journal: Med Klin Intensivmed Notfmed Date: 2013-03-03 Impact factor: 0.840
Authors: Roeland H A Passier; Andrew R Davies; Emma Ridley; Jason McClure; Deirdre Murphy; Carlos D Scheinkestel Journal: Intensive Care Med Date: 2013-05-01 Impact factor: 17.440
Authors: Gisele Trennepohl da Costa Heinen; Daniella Schmit; Denise Johnsson Campos; Carmem Bonfim; Estela Iraci Rabito; Regina Maria Vilela Journal: Support Care Cancer Date: 2017-10-03 Impact factor: 3.603
Authors: Valeska Fernandes Pasinato; Marina Carvalho Berbigier; Bibiana de Almeida Rubin; Kamila Castro; Rafael Barberena Moraes; Ingrid Dalira Schweigert Perry Journal: Rev Bras Ter Intensiva Date: 2013-03