Literature DB >> 20939602

Coating optimization of superparamagnetic iron oxide nanoparticles for high T2 relaxivity.

Sheng Tong1, Sijian Hou, Zhilan Zheng, Jun Zhou, Gang Bao.   

Abstract

We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

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Year:  2010        PMID： 20939602      PMCID： PMC3170660          DOI： 10.1021/nl102623x

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  27 in total

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