Literature DB >> 20936490

Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex.

C Pichardo1, M C Conejo, F Docobo-Pérez, C Velasco, R López-Rojas, I García, M E Pachón-Ibáñez, J M Rodríguez, J Pachón, A Pascual.   

Abstract

Zinc eluted from siliconized latex (SL) increases resistance of Pseudomonas aeruginosa to imipenem in vitro. A foreign body peritonitis model was used to evaluate the activity of imipenem using SL or silicone (S) implants. No differences were observed in mortality, positive blood cultures and tissue bacterial counts between SL and S implants. Implant-associated counts, however, were significantly higher in the SL group. It is concluded that SL decreases the activity of imipenem against P. aeruginosa.

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Year:  2010        PMID： 20936490     DOI： 10.1007/s10096-010-1084-y

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN： 0934-9723            Impact factor:   3.267


  6 in total

Review 1.  [Urinary tract infections].

Authors:  José Juan Hernández-Burruezo; Mohamed Omar Mohamed-Balghata; Luis Aliaga Martínez
Journal:  Med Clin (Barc)       Date:  2007-11-17       Impact factor: 1.725

2.  Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America.

Authors:  Thomas M Hooton; Suzanne F Bradley; Diana D Cardenas; Richard Colgan; Suzanne E Geerlings; James C Rice; Sanjay Saint; Anthony J Schaeffer; Paul A Tambayh; Peter Tenke; Lindsay E Nicolle
Journal:  Clin Infect Dis       Date:  2010-03-01       Impact factor: 9.079

3.  CzcR-CzcS, a two-component system involved in heavy metal and carbapenem resistance in Pseudomonas aeruginosa.

Authors:  Karl Perron; Olivier Caille; Claude Rossier; Christian Van Delden; Jean-Luc Dumas; Thilo Köhler
Journal:  J Biol Chem       Date:  2003-12-15       Impact factor: 5.157

4.  Effect of siliconized latex urinary catheters on the activity of carbapenems against Pseudomonas aeruginosa strains with defined mutations in ampC, oprD, and genes coding for efflux systems.

Authors:  M Carmen Conejo; Luis Martínez-Martínez; Isabel García; Leandro Picabea; Alvaro Pascual
Journal:  Int J Antimicrob Agents       Date:  2003-08       Impact factor: 5.283

5.  Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations.

Authors:  L Martínez-Martínez; A Pascual; M C Conejo; L Picabea; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1999-02       Impact factor: 5.191

6.  Zinc eluted from siliconized latex urinary catheters decreases OprD expression, causing carbapenem resistance in Pseudomonas aeruginosa.

Authors:  M Carmen Conejo; Isabel García; Luis Martínez-Martínez; Leandro Picabea; Alvaro Pascual
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191
  6 in total
  1 in total

1.  Efficacy of daptomycin versus vancomycin in an experimental model of foreign-body and systemic infection caused by biofilm producers and methicillin-resistant Staphylococcus epidermidis.

Authors:  J Domínguez-Herrera; F Docobo-Pérez; R López-Rojas; C Pichardo; R Ruiz-Valderas; J A Lepe; J Pachón
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191
  1 in total

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