Literature DB >> 20935316

Synthetic biology and the ethics of knowledge.

Thomas Douglas1, Julian Savulescu.   

Abstract

Synthetic biologists aim to generate biological organisms according to rational design principles. Their work may have many beneficial applications, but it also raises potentially serious ethical concerns. In this article, we consider what attention the discipline demands from bioethicists. We argue that the most important issue for ethicists to examine is the risk that knowledge from synthetic biology will be misused, for example, in biological terrorism or warfare. To adequately address this concern, bioethics will need to broaden its scope, contemplating not just the means by which scientific knowledge is produced, but also what kinds of knowledge should be sought and disseminated.

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Year:  2010        PMID: 20935316      PMCID: PMC3045879          DOI: 10.1136/jme.2010.038232

Source DB:  PubMed          Journal:  J Med Ethics        ISSN: 0306-6800            Impact factor:   2.903


  25 in total

1.  Policy forum: genetics. Ethical considerations in synthesizing a minimal genome.

Authors:  M K Cho; D Magnus; A L Caplan; D McGee
Journal:  Science       Date:  1999-12-10       Impact factor: 47.728

2.  Uncensored exchange of scientific results.

Authors:  Ronald Atlas; Philip Campbell; Nicholas R Cozzarelli; Greg Curfman; Lynn Enquist; Gerald Fink; Annette Flanagin; Jacqueline Fletcher; Elizabeth George; Gordon Hammes; David Heyman; Thomas Inglesby; Samuel Kaplan; Donald Kennedy; Judith Krug; Rachel E Levinson; Emilie Marcus; Henry Metzger; Stephen S Morse; Alison O'Brien; Andrew Onderdonk; George Poste; Beatrice Renault; Robert Rich; Ariella Rosengard; Steven Salzberg; Steven Salzburg; Mary Scanlan; Thomas Shenk; Herbert Tabor; Harold Varmus; Eckard Wimmer; Keith Yamamoto
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-15       Impact factor: 11.205

3.  Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template.

Authors:  Jeronimo Cello; Aniko V Paul; Eckard Wimmer
Journal:  Science       Date:  2002-07-11       Impact factor: 47.728

4.  Computational design of receptor and sensor proteins with novel functions.

Authors:  Loren L Looger; Mary A Dwyer; James J Smith; Homme W Hellinga
Journal:  Nature       Date:  2003-05-08       Impact factor: 49.962

5.  Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

Authors:  R J Jackson; A J Ramsay; C D Christensen; S Beaton; D F Hall; I A Ramshaw
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

6.  Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.

Authors:  B A Pfeifer; S J Admiraal; H Gramajo; D E Cane; C Khosla
Journal:  Science       Date:  2001-03-02       Impact factor: 47.728

7.  Creation of a bacterial cell controlled by a chemically synthesized genome.

Authors:  Daniel G Gibson; John I Glass; Carole Lartigue; Vladimir N Noskov; Ray-Yuan Chuang; Mikkel A Algire; Gwynedd A Benders; Michael G Montague; Li Ma; Monzia M Moodie; Chuck Merryman; Sanjay Vashee; Radha Krishnakumar; Nacyra Assad-Garcia; Cynthia Andrews-Pfannkoch; Evgeniya A Denisova; Lei Young; Zhi-Qing Qi; Thomas H Segall-Shapiro; Christopher H Calvey; Prashanth P Parmar; Clyde A Hutchison; Hamilton O Smith; J Craig Venter
Journal:  Science       Date:  2010-05-20       Impact factor: 47.728

8.  Generating a synthetic genome by whole genome assembly: phiX174 bacteriophage from synthetic oligonucleotides.

Authors:  Hamilton O Smith; Clyde A Hutchison; Cynthia Pfannkoch; J Craig Venter
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-02       Impact factor: 11.205

9.  Engineering a mevalonate pathway in Escherichia coli for production of terpenoids.

Authors:  Vincent J J Martin; Douglas J Pitera; Sydnor T Withers; Jack D Newman; Jay D Keasling
Journal:  Nat Biotechnol       Date:  2003-06-01       Impact factor: 54.908

Review 10.  Bacteria as tumour-targeting vectors.

Authors:  John M Pawelek; K Brooks Low; David Bermudes
Journal:  Lancet Oncol       Date:  2003-09       Impact factor: 41.316

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  9 in total

1.  One health security: an important component of the global health security agenda.

Authors:  Gigi Gronvall; Crystal Boddie; Rickard Knutsson; Michelle Colby
Journal:  Biosecur Bioterror       Date:  2014 Sep-Oct

2.  Integrating ethical analysis "into the DNA" of synthetic biology.

Authors:  Patrick Heavey
Journal:  Med Health Care Philos       Date:  2015-02

3.  H5N1 avian flu research and the ethics of knowledge.

Authors:  David B Resnik
Journal:  Hastings Cent Rep       Date:  2013-02-06       Impact factor: 2.683

4.  Synthetic Biology, Genome Editing, and the Risk of Bioterrorism.

Authors:  Marko Ahteensuu
Journal:  Sci Eng Ethics       Date:  2017-01-10       Impact factor: 3.777

5.  Engineering and ethical perspectives in synthetic biology. Rigorous, robust and predictable designs, public engagement and a modern ethical framework are vital to the continued success of synthetic biology.

Authors:  James Anderson; Natalja Strelkowa; Guy-Bart Stan; Thomas Douglas; Julian Savulescu; Mauricio Barahona; Antonis Papachristodoulou
Journal:  EMBO Rep       Date:  2012-06-29       Impact factor: 8.807

Review 6.  Building genomes to understand biology.

Authors:  Alessandro L V Coradini; Cara B Hull; Ian M Ehrenreich
Journal:  Nat Commun       Date:  2020-12-02       Impact factor: 14.919

7.  Synthetic Biology: Old and New Dilemmas-The Case of Artificial Life.

Authors:  Nikolaos Kolisis; Fragiskos Kolisis
Journal:  BioTech (Basel)       Date:  2021-07-20

8.  Is the creation of artificial life morally significant?

Authors:  Thomas Douglas; Russell Powell; Julian Savulescu
Journal:  Stud Hist Philos Biol Biomed Sci       Date:  2013-06-27

9.  Research Translation and Emerging Health Technologies: Synthetic Biology and Beyond.

Authors:  Sarah Chan
Journal:  Health Care Anal       Date:  2018-12
  9 in total

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