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Literature DB >> 209353

Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes.

A H Mulder, C D de Langen, V de Regt, F Hogenboom.

Abstract

The effects of oxymetazoline and noradrenaline (in the presence of desipramine) on the release of 3H-noradrenaline from rat brain cortex synaptosomes were studied using a superfusion technique. Both drugs (at 1 micrometer concentrations) were found to reduce the depolarization-induced (15 mM K+) release of 3H-noradrenaline. The release-modulating effect of noradrenaline was antagonized by phentolamine and yohimbine. The data provide direct evidence for the hypothesis that alpha-receptors modulating the release of noradrenaline are localized on varicosities of central noradrenergic neurones.

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Year: 1978 PMID： 209353 DOI： 10.1007/bf00508068

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

11 in total

1. On the mechanism of alpha-receptor mediated modulation of 3H-noradrenaline release from slices of rat brain neocortex.

Authors: K Dismukes; A A de Boer; A H Mulder
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-09 Impact factor: 3.000

Review 2. Presynaptic alpha-adrenoceptors.

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Journal: Gen Pharmacol Date: 1976-10

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Authors: H D Taube; K Starke; E Borowski
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-09 Impact factor: 3.000

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Authors: S Z Langer
Journal: Br J Pharmacol Date: 1977-08 Impact factor: 8.739

5. Calcium-dependent release of radiolabeled catecholamines and serotonin from rat brain synaptosomes in a superfusion system.

Authors: A H Mulder; W B van den Berg; J C Stoof
Journal: Brain Res Date: 1975-12-05 Impact factor: 3.252

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Authors: K Starke; H Montel
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1973 Impact factor: 3.000

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Authors: L O Farnebo; B Hamberger
Journal: Acta Physiol Scand Suppl Date: 1971

8. A method for the isolation and determination of 3-methoxytyramine in brain tissue.

Authors: W Kehr
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1974 Impact factor: 3.000

9. A noradren aline sensitive adenylate cyclase in the rat limbic forebrain: preparation, properties and the effects of agonists, adrenolytics and neuroleptic drugs.

Authors: A S Horn; O T Phillipson
Journal: Eur J Pharmacol Date: 1976-05 Impact factor: 4.432

10. Cyclic AMP and alpha-receptor-mediated modulation of noradrenaling release from rat brain slices.

Authors: R K Dismukes; A H Mulder
Journal: Eur J Pharmacol Date: 1976-10 Impact factor: 4.432

14 in total

1. Presynaptic opioid receptors on noradrenergic and serotonergic neurons in the human as compared to the rat neocortex.

Authors: Benjamin Berger; Anna Katharina Rothmaier; Franziska Wedekind; Josef Zentner; Thomas J Feuerstein; Rolf Jackisch
Journal: Br J Pharmacol Date: 2006-06-05 Impact factor: 8.739

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Journal: J Neural Transm Date: 1988 Impact factor: 3.575

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Authors: M J van Veldhuizen; M G Feenstra; R P Heinsbroek; G J Boer
Journal: Br J Pharmacol Date: 1993-07 Impact factor: 8.739

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Authors: J Wemer; A N Schoffelmeer; A H Mulder
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1981-09 Impact factor: 3.000

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Authors: M Göthert; I M Pohl; E Wehking
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1979-05 Impact factor: 3.000

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Authors: R P Ebstein; B Lerer; M Shlaufman; R H Belmaker
Journal: Cell Mol Neurobiol Date: 1983-09 Impact factor: 5.046

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Authors: R P Ebstein; J W Daly
Journal: Cell Mol Neurobiol Date: 1982-09 Impact factor: 5.046

9. Releasing activities of d-fenfluramine and fluoxetine on rat hippocampal synaptosomes preloaded with [3H]serotonin.

Authors: M Gobbi; E Frittoli; T Mennini; S Garattini
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1992-01 Impact factor: 3.000

10. Differential blockade by (-)mianserin of the alpha 2-adrenoceptors mediating inhibition of noradrenaline and serotonin release from rat brain synaptosomes.

Authors: M Raiteri; G Maura; A Gemignani; A Pittaluga
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1983-03 Impact factor: 3.000