Literature DB >> 185066

Cyclic AMP and alpha-receptor-mediated modulation of noradrenaling release from rat brain slices.

R K Dismukes, A H Mulder.   

Abstract

Oxymetazoline (an alpha-receptor agonist) reduced and phentolamine (an alpha-receptor antagonist) increased depolarization-induced release (potassium or electrical field stimulation) of 3H-noradrenaline (NA) from superfused neocortical slices in a dose-dependent way. Inhibition of phosphodiesterase also reduced NA release; this effect could be reversed by phentolamine. Phosphodiesterase inhibition potentiated the effect of oxymetazoline. It is suggested that stimulation of presynaptic alpha-receptors may reduce NA release up to about 60% and that increased cyclic AMP formation might be involved in this modulation.

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Year:  1976        PMID： 185066     DOI： 10.1016/0014-2999(76)90148-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  On the mechanism of alpha-receptor mediated modulation of 3H-noradrenaline release from slices of rat brain neocortex.

Authors:  K Dismukes; A A de Boer; A H Mulder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-09       Impact factor: 3.000

2.  Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes.

Authors:  A H Mulder; C D de Langen; V de Regt; F Hogenboom
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-06       Impact factor: 3.000

3.  Presynaptic receptor systems on the noradrenergic neurones of rat brain.

Authors:  H D Taube; K Starke; E Borowski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-09       Impact factor: 3.000

Review 4.  Sixth gaddum memorial lecture, National Institute for Medical Research, Mill Hill, January 1977. Presynaptic receptors and their role in the regulation of transmitter release.

Authors:  S Z Langer
Journal:  Br J Pharmacol       Date:  1977-08       Impact factor: 8.739

5.  Release of norepinephrine from brain vesicular preparations: effects of an adenylate cyclase activator, forskolin, and a phosphodiesterase inhibitor.

Authors:  R P Ebstein; K Seamon; C R Creveling; J W Daly
Journal:  Cell Mol Neurobiol       Date:  1982-09       Impact factor: 5.046

6.  Effects of neuroleptics on release of 3H-dopamine from slices of rat corpus striatum.

Authors:  K Dismukes; A H Mulder
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-03       Impact factor: 3.000

7.  Effects of presynaptic modulators on Ca2+-induced noradrenaline release from central noradrenergic neurons. Noradrenaline and enkephalin inhibit release by decreasing depolarization-induced Ca2+ influx.

Authors:  M Göthert; I M Pohl; E Wehking
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-05       Impact factor: 3.000

8.  Catecholamine metabolism in rat brain following the intracerebroventricular administration of cyclic nucleotides.

Authors:  W Kehr; G Debus; H M Thiede
Journal:  J Neural Transm       Date:  1982       Impact factor: 3.575

9.  Forskolin and the release of noradrenaline in cerebrocortical slices.

Authors:  R Markstein; K Digges; N R Marshall; K Starke
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-01       Impact factor: 3.000
  9 in total

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