Literature DB >> 20935125

Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening.

Bradley R Borlee1, Grant D Geske, Helen E Blackwell, Jo Handelsman.   

Abstract

We report the screening of 16,000 synthetic compounds for induction and inhibition of quorum sensing in a Pseudomonas putida N-acylated l-homoserine lactone (AHL) sensor strain engineered with the LasR transcriptional activator. LasR controls virulence gene expression in the opportunistic pathogen Pseudomonas aeruginosa and is of significant interest as a therapeutic target. Nine compounds that inhibit and 14 compounds that induce LasR activity were identified in our high-throughput screen.

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Year:  2010        PMID： 20935125      PMCID： PMC3008242          DOI： 10.1128/AEM.00499-10

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  15 in total

1.  Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.

Authors:  J P Pearson; M Feldman; B H Iglewski; A Prince
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

Review 2.  Bacterial signals and antagonists: the interaction between bacteria and higher organisms.

Authors:  S A Rice; M Givskov; P Steinberg; S Kjelleberg
Journal:  J Mol Microbiol Biotechnol       Date:  1999-08

Review 3.  Inhibitors and antagonists of bacterial quorum sensing.

Authors:  Nanting Ni; Minyong Li; Junfeng Wang; Binghe Wang
Journal:  Med Res Rev       Date:  2009-01       Impact factor: 12.944

4.  gfp-based N-acyl homoserine-lactone sensor systems for detection of bacterial communication.

Authors:  J B Andersen; A Heydorn; M Hentzer; L Eberl; O Geisenberger; B B Christensen; S Molin; M Givskov
Journal:  Appl Environ Microbiol       Date:  2001-02       Impact factor: 4.792

5.  Delays in Pseudomonas aeruginosa quorum-controlled gene expression are conditional.

Authors:  Jeremy M Yarwood; Esther M Volper; E Peter Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-13       Impact factor: 11.205

Review 6.  Quorum-sensing inhibitors as anti-pathogenic drugs.

Authors:  Thomas B Rasmussen; Michael Givskov
Journal:  Int J Med Microbiol       Date:  2006-02-28       Impact factor: 3.473

Review 7.  Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing.

Authors:  C Fuqua; M R Parsek; E P Greenberg
Journal:  Annu Rev Genet       Date:  2001       Impact factor: 16.830

8.  A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Authors:  Ute Müh; Brian J Hare; Breck A Duerkop; Martin Schuster; Brian L Hanzelka; Roger Heim; Eric R Olson; E Peter Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-30       Impact factor: 11.205

Review 9.  Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria.

Authors:  Grant D Geske; Jennifer C O'Neill; Helen E Blackwell
Journal:  Chem Soc Rev       Date:  2008-06-02       Impact factor: 54.564

10.  Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer.

Authors:  Matthew J Bottomley; Ester Muraglia; Renzo Bazzo; Andrea Carfì
Journal:  J Biol Chem       Date:  2007-03-15       Impact factor: 5.157
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  25 in total

1.  Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor.

Authors:  Mario J Lintz; Ken-ichi Oinuma; Christina L Wysoczynski; Everett Peter Greenberg; Mair E A Churchill
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-12       Impact factor: 11.205

2.  Poly(ε-lysine) dendrons as modulators of quorum sensing in Pseudomonas aeruginosa.

Authors:  Rahaf Issa; Steve T Meikle; Stuart James; Ian R Cooper
Journal:  J Mater Sci Mater Med       Date:  2015-04-17       Impact factor: 3.896

3.  Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands.

Authors:  Christina L Wysoczynski-Horita; Michelle E Boursier; Ryan Hill; Kirk Hansen; Helen E Blackwell; Mair E A Churchill
Journal:  Mol Microbiol       Date:  2018-03-11       Impact factor: 3.501

Review 4.  Bacterial quorum sensing: its role in virulence and possibilities for its control.

Authors:  Steven T Rutherford; Bonnie L Bassler
Journal:  Cold Spring Harb Perspect Med       Date:  2012-11-01       Impact factor: 6.915

Review 5.  Exploiting quorum sensing to confuse bacterial pathogens.

Authors:  Breah LaSarre; Michael J Federle
Journal:  Microbiol Mol Biol Rev       Date:  2013-03       Impact factor: 11.056

6.  Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.

Authors:  Bryan D Yestrepsky; Yuanxi Xu; Meghan E Breen; Xiaoqin Li; Walajapet G Rajeswaran; Jenny G Ryu; Roderick J Sorenson; Yasuhiro Tsume; Michael W Wilson; Wenpeng Zhang; Duxin Sun; Hongmin Sun; Scott D Larsen
Journal:  Bioorg Med Chem       Date:  2013-02-01       Impact factor: 3.641

7.  Effects of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa.

Authors:  Li Ma; Xiangyang Liu; Haihua Liang; Yizhou Che; Caixia Chen; Huanqin Dai; Ke Yu; Mei Liu; Luyan Ma; Ching-Hong Yang; Fuhang Song; Yuqiang Wang; Lixin Zhang
Journal:  Antimicrob Agents Chemother       Date:  2012-07-16       Impact factor: 5.191

Review 8.  Progress in and promise of bacterial quorum sensing research.

Authors:  Marvin Whiteley; Stephen P Diggle; E Peter Greenberg
Journal:  Nature       Date:  2017-11-15       Impact factor: 49.962

9.  Structural determinants driving homoserine lactone ligand selection in the Pseudomonas aeruginosa LasR quorum-sensing receptor.

Authors:  Amelia R McCready; Jon E Paczkowski; Brad R Henke; Bonnie L Bassler
Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-17       Impact factor: 11.205

10.  Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.

Authors:  Fei Sun; Lu Zhou; Bing-Chuan Zhao; Xin Deng; Hoonsik Cho; Chengqi Yi; Xing Jian; Chun-Xiao Song; Chi-Hao Luan; Taeok Bae; Zigang Li; Chuan He
Journal:  Chem Biol       Date:  2011-08-26
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