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Literature DB >> 10858254

Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection.

J P Pearson¹, M Feldman, B H Iglewski, A Prince.

Abstract

Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa. We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.

Entities: Chemical Disease Species

Mesh：

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Year: 2000 PMID： 10858254 PMCID： PMC101761 DOI： 10.1128/IAI.68.7.4331-4334.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

32 in total

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Authors: K V Rolston; J J Tarrand
Journal: Clin Infect Dis Date: 1999-08 Impact factor: 9.079

Review 2. The chain of command in Pseudomonas quorum sensing.

Authors: E C Pesci; B H Iglewski
Journal: Trends Microbiol Date: 1997-04 Impact factor: 17.079

3. Roles of Pseudomonas aeruginosa las and rhl quorum-sensing systems in control of elastase and rhamnolipid biosynthesis genes.

Authors: J P Pearson; E C Pesci; B H Iglewski
Journal: J Bacteriol Date: 1997-09 Impact factor: 3.490

4. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa.

Authors: M Whiteley; K M Lee; E P Greenberg
Journal: Proc Natl Acad Sci U S A Date: 1999-11-23 Impact factor: 11.205

5. Contribution of quorum sensing to the virulence of Pseudomonas aeruginosa in burn wound infections.

Authors: K P Rumbaugh; J A Griswold; B H Iglewski; A N Hamood
Journal: Infect Immun Date: 1999-11 Impact factor: 3.441

6. Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

Authors: M W Tan; L G Rahme; J A Sternberg; R G Tompkins; F M Ausubel
Journal: Proc Natl Acad Sci U S A Date: 1999-03-02 Impact factor: 11.205

7. PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence.

Authors: A R Hauser; P J Kang; J N Engel
Journal: Mol Microbiol Date: 1998-02 Impact factor: 3.501

8. Nosocomial bloodstream infections in United States hospitals: a three-year analysis.

Authors: M B Edmond; S E Wallace; D K McClish; M A Pfaller; R N Jones; R P Wenzel
Journal: Clin Infect Dis Date: 1999-08 Impact factor: 9.079

9. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals.

Authors: J P Pearson; C Van Delden; B H Iglewski
Journal: J Bacteriol Date: 1999-02 Impact factor: 3.490

10. In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections.

Authors: T Sawa; M Ohara; K Kurahashi; S S Twining; D W Frank; D B Doroques; T Long; M A Gropper; J P Wiener-Kronish
Journal: Infect Immun Date: 1998-07 Impact factor: 3.441

103 in total

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Authors: T R de Kievit; B H Iglewski
Journal: Infect Immun Date: 2000-09 Impact factor: 3.441

Review 2. Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance.

Authors: José L Martínez; Fernando Baquero
Journal: Clin Microbiol Rev Date: 2002-10 Impact factor: 26.132

3. Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors.

Authors: Morten Hentzer; Hong Wu; Jens Bo Andersen; Kathrin Riedel; Thomas B Rasmussen; Niels Bagge; Naresh Kumar; Mark A Schembri; Zhijun Song; Peter Kristoffersen; Mike Manefield; John W Costerton; Søren Molin; Leo Eberl; Peter Steinberg; Staffan Kjelleberg; Niels Høiby; Michael Givskov
Journal: EMBO J Date: 2003-08-01 Impact factor: 11.598

Review 4. The multiple signaling systems regulating virulence in Pseudomonas aeruginosa.

Authors: Pol Nadal Jimenez; Gudrun Koch; Jessica A Thompson; Karina B Xavier; Robbert H Cool; Wim J Quax
Journal: Microbiol Mol Biol Rev Date: 2012-03 Impact factor: 11.056

Review 5. ppGpp conjures bacterial virulence.

Authors: Zachary D Dalebroux; Sarah L Svensson; Erin C Gaynor; Michele S Swanson
Journal: Microbiol Mol Biol Rev Date: 2010-06 Impact factor: 11.056

6. Methylthioinosine phosphorylase from Pseudomonas aeruginosa. Structure and annotation of a novel enzyme in quorum sensing.

Authors: Rong Guan; Meng-Chiao Ho; Steven C Almo; Vern L Schramm
Journal: Biochemistry Date: 2011-01-25 Impact factor: 3.162

7. Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation.

Authors: Amanda L Garner; Jing Yu; Anjali Kumari Struss; Colin A Lowery; Jie Zhu; Sook Kyung Kim; Junguk Park; Alexander V Mayorov; Gunnar F Kaufmann; Vladimir V Kravchenko; Kim D Janda
Journal: Bioorg Med Chem Lett Date: 2010-12-04 Impact factor: 2.823

8. Identification of synthetic inducers and inhibitors of the quorum-sensing regulator LasR in Pseudomonas aeruginosa by high-throughput screening.

Authors: Bradley R Borlee; Grant D Geske; Helen E Blackwell; Jo Handelsman
Journal: Appl Environ Microbiol Date: 2010-10-08 Impact factor: 4.792

Review 9. Alternative sigma factors and their roles in bacterial virulence.

Authors: Mark J Kazmierczak; Martin Wiedmann; Kathryn J Boor
Journal: Microbiol Mol Biol Rev Date: 2005-12 Impact factor: 11.056

10. A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal.

Authors: Ute Müh; Brian J Hare; Breck A Duerkop; Martin Schuster; Brian L Hanzelka; Roger Heim; Eric R Olson; E Peter Greenberg
Journal: Proc Natl Acad Sci U S A Date: 2006-10-30 Impact factor: 11.205