Literature DB >> 209345

Binding of (3H)dihydroalprenolol to beta adrenoceptors of cells isolated from adult rat heart.

E Moustafa, A Giachetti, H F Downey, F A Bashour.   

Abstract

Myocardial cells isolated from adult rat heart bind (3H)dihydroalprenolol. Sixty-one percent of this binding appeared to be at the beta adrenoceptors since it was inhibited by saturating quantities of the beta antagonist propranolol or by the beta agonist isoprenaline. The binding is stereoselective as the l-isomer of isoprenaline caused greater inhibition than the d-isomer. The binding of (3H)dihydroalprenolol to beta adrenoceptors was saturable; half maximum binding occurred at about 8 nM and full saturation at 30--40nM.

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Year:  1978        PMID： 209345     DOI： 10.1007/bf00496192

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  5 in total

1.  Beta adrenergic receptor binding in membrane preparations from mammalian brain.

Authors:  D B Bylund; S H Snyder
Journal:  Mol Pharmacol       Date:  1976-07       Impact factor: 4.436

2.  Correlation of the glycoside response, the force staircase, and the action potential configuration in the neonatal rat heart.

Authors:  G A Langer; A J Brady; S T Tan; D Serena
Journal:  Circ Res       Date:  1975-06       Impact factor: 17.367

3.  Cyclic AMP formation and morphology of myocardial cells isolated from adult heart: effect of Ca2+ and Mg2+.

Authors:  E Moustafa; T Skomedal; J B Osnes; I Oye
Journal:  Biochim Biophys Acta       Date:  1976-02-24

4.  Control of cardiac sarcolemmal adenylate cyclase and sodium, potassium-activated adenosinetriphosphatase activities.

Authors:  M Tada; M A Kirchberger; J M Iorio; A M Katz
Journal:  Circ Res       Date:  1975-01       Impact factor: 17.367

5.  Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding.

Authors:  R W Alexander; L T Williams; R J Lefkowitz
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205
  5 in total
  4 in total

1.  Characterization of cell-surface beta-adrenergic ([3H]CGP-12177) binding in adult rat ventricular myocytes: lack of regulation by beta-agonists at physiological concentrations.

Authors:  M Horackova; M Wilkinson
Journal:  Pflugers Arch       Date:  1992-08       Impact factor: 3.657

Review 2.  Are isolated cardiomyocytes a suitable experimental model in all lines of investigation in basic cardiology?

Authors:  H Kammermeier; H Rose
Journal:  Basic Res Cardiol       Date:  1988 Jul-Aug       Impact factor: 17.165

3.  Direct labelling of myocardial beta 1-adrenoceptors. Comparison of binding affinity of 3H-(-)-bisoprolol with its blocking potency.

Authors:  A J Kaumann; H Lemoine
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-10       Impact factor: 3.000

4.  Temperature related effects on the binding characteristics of beta-adrenergic receptor agonists and antagonists by rabbit lung.

Authors:  R J Altiere; J S Douglas; C N Gillis
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-07       Impact factor: 3.000
  4 in total

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