Literature DB >> 20930546

Global DNA methylation levels in girls with and without a family history of breast cancer.

Hui-Chen Wu1, Esther M John, Jennifer S Ferris, Theresa H Keegan, Wendy K Chung, Irene Andrulis, Lissette Delgado-Cruzata, Maya Kappil, Karina Gonzalez, Regina M Santella, Mary Beth Terry.   

Abstract

Lower levels of global DNA methylation in white blood cell (WBC) DNA have been associated with adult cancers. It is unknown whether individuals with a family history of cancer also have lower levels of global DNA methylation early in life. We examined global DNA methylation in WBC (measured in three repetitive elements, LINE1, Sat2 and Alu, by MethyLight and in LINE1 by pyrosequencing) in 51 girls ages 6-17. Compared to girls without a family history of breast cancer, methylation levels were lower for all assays in girls with a family history of breast cancer, and statistically significantly lower for Alu and LINE1 pyrosequencing. After adjusting for age, body mass index (BMI), and Tanner stage, only methylation in Alu was associated with family history of breast cancer. If these findings are replicated in larger studies, they suggest that lower levels of global WBC DNA methylation observed later in life in adults with cancer may also be present early in life in children with a family history of cancer.

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Year:  2011        PMID： 20930546      PMCID： PMC3052913          DOI： 10.4161/epi.6.1.13393

Source DB:  PubMed          Journal:  Epigenetics        ISSN： 1559-2294            Impact factor:   4.528


  24 in total

1.  Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.

Authors:  G C Rampersaud; G P Kauwell; A D Hutson; J J Cerda; L B Bailey
Journal:  Am J Clin Nutr       Date:  2000-10       Impact factor: 7.045

2.  DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.

Authors:  M Esteller; M F Fraga; M Guo; J Garcia-Foncillas; I Hedenfalk; A K Godwin; J Trojan; C Vaurs-Barrière; Y J Bignon; S Ramus; J Benitez; T Caldes; Y Akiyama; Y Yuasa; V Launonen; M J Canal; R Rodriguez; G Capella; M A Peinado; A Borg; L A Aaltonen; B A Ponder; S B Baylin; J G Herman
Journal:  Hum Mol Genet       Date:  2001-12-15       Impact factor: 6.150

3.  Early life factors in relation to breast cancer risk in postmenopausal women.

Authors:  Linda Titus-Ernstoff; Kathleen M Egan; Polly A Newcomb; Jiao Ding; Amy Trentham-Dietz; E Robert Greenberg; John A Baron; Dimitrios Trichopoulos; Walter C Willett
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2002-02       Impact factor: 4.254

4.  Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.

Authors:  Carrie V Breton; Hyang-Min Byun; Made Wenten; Fei Pan; Allen Yang; Frank D Gilliland
Journal:  Am J Respir Crit Care Med       Date:  2009-06-04       Impact factor: 21.405

5.  Genomic DNA methylation among women in a multiethnic New York City birth cohort.

Authors:  Mary Beth Terry; Jennifer S Ferris; Richard Pilsner; Julie D Flom; Parisa Tehranifar; Regina M Santella; Mary V Gamble; Ezra Susser
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-09       Impact factor: 4.254

6.  Intra-individual change over time in DNA methylation with familial clustering.

Authors:  Hans T Bjornsson; Martin I Sigurdsson; M Daniele Fallin; Rafael A Irizarry; Thor Aspelund; Hengmi Cui; Wenqiang Yu; Michael A Rongione; Tomas J Ekström; Tamara B Harris; Lenore J Launer; Gudny Eiriksdottir; Mark F Leppert; Carmen Sapienza; Vilmundur Gudnason; Andrew P Feinberg
Journal:  JAMA       Date:  2008-06-25       Impact factor: 56.272

7.  Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study.

Authors:  Lee E Moore; Ruth M Pfeiffer; Cristina Poscablo; Francisco X Real; Manolis Kogevinas; Debra Silverman; Reina García-Closas; Stephen Chanock; Adonina Tardón; Consol Serra; Alfredo Carrato; Mustafa Dosemeci; Montserrat García-Closas; Manel Esteller; Mario Fraga; Nathaniel Rothman; Núria Malats
Journal:  Lancet Oncol       Date:  2008-03-12       Impact factor: 41.316

8.  DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.

Authors:  Elmar W Tobi; L H Lumey; Rudolf P Talens; Dennis Kremer; Hein Putter; Aryeh D Stein; P Eline Slagboom; Bastiaan T Heijmans
Journal:  Hum Mol Genet       Date:  2009-08-04       Impact factor: 6.150

9.  Global and gene-specific promoter methylation changes are related to anti-B[a]PDE-DNA adduct levels and influence micronuclei levels in polycyclic aromatic hydrocarbon-exposed individuals.

Authors:  Sofia Pavanello; Valentina Bollati; Angela Cecilia Pesatori; Lucyna Kapka; Claudia Bolognesi; Pier Alberto Bertazzi; Andrea Baccarelli
Journal:  Int J Cancer       Date:  2009-10-01       Impact factor: 7.396

10.  Association between global DNA hypomethylation in leukocytes and risk of breast cancer.

Authors:  Ji-Yeob Choi; Smitha R James; Petra A Link; Susan E McCann; Chi-Chen Hong; Warren Davis; Mary K Nesline; Christine B Ambrosone; Adam R Karpf
Journal:  Carcinogenesis       Date:  2009-07-07       Impact factor: 4.944
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  23 in total

1.  Cardiovascular disease risk factors and DNA methylation at the LINE-1 repeat region in peripheral blood from Samoan Islanders.

Authors:  Haley L Cash; Stephen T McGarvey; E Andrés Houseman; Carmen J Marsit; Nicola L Hawley; Geralyn M Lambert-Messerlian; Satupaitea Viali; John Tuitele; Karl T Kelsey
Journal:  Epigenetics       Date:  2011-10-01       Impact factor: 4.528

2.  Global DNA methylation levels in white blood cells as a biomarker for hepatocellular carcinoma risk: a nested case-control study.

Authors:  Hui-Chen Wu; Qiao Wang; Hwai-I Yang; Wei-Yann Tsai; Chien-Jen Chen; Regina M Santella
Journal:  Carcinogenesis       Date:  2012-05-12       Impact factor: 4.944

3.  Progressive changes in chromatin structure and DNA damage response signals in bone marrow and peripheral blood during myelomagenesis.

Authors:  M Gkotzamanidou; E Terpos; C Bamia; S A Kyrtopoulos; P P Sfikakis; M A Dimopoulos; V L Souliotis
Journal:  Leukemia       Date:  2013-10-03       Impact factor: 11.528

4.  Differences in DNA methylation by extent of breast cancer family history in unaffected women.

Authors:  Lissette Delgado-Cruzata; Hui-Chen Wu; Yuyan Liao; Regina M Santella; Mary Beth Terry
Journal:  Epigenetics       Date:  2013-10-29       Impact factor: 4.528

5.  Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues.

Authors:  Adana A M Llanos; Catalin Marian; Theodore M Brasky; Ramona G Dumitrescu; Zhenhua Liu; Joel B Mason; Kepher H Makambi; Scott L Spear; Bhaskar V S Kallakury; Jo L Freudenheim; Peter G Shields
Journal:  Epigenetics       Date:  2015       Impact factor: 4.528

6.  Breast cancer family history and allele-specific DNA methylation in the legacy girls study.

Authors:  Hui-Chen Wu; Catherine Do; Irene L Andrulis; Esther M John; Mary B Daly; Saundra S Buys; Wendy K Chung; Julia A Knight; Angela R Bradbury; Theresa H M Keegan; Lisa Schwartz; Izabela Krupska; Rachel L Miller; Regina M Santella; Benjamin Tycko; Mary Beth Terry
Journal:  Epigenetics       Date:  2018-04-02       Impact factor: 4.528

Review 7.  DNA methylation as a promising landscape: A simple blood test for breast cancer prediction.

Authors:  Golnaz Khakpour; Arash Pooladi; Pantea Izadi; Mehrdad Noruzinia; Javad Tavakkoly Bazzaz
Journal:  Tumour Biol       Date:  2015-06-16

8.  No effect of weight loss on LINE-1 methylation levels in peripheral blood leukocytes from postmenopausal overweight women.

Authors:  Catherine Duggan; Liren Xiao; Mary Beth Terry; Anne McTiernan
Journal:  Obesity (Silver Spring)       Date:  2014-06-13       Impact factor: 5.002

9.  Epigenome-wide association study of breast cancer using prospectively collected sister study samples.

Authors:  Zongli Xu; Sophia C E Bolick; Lisa A DeRoo; Clarice R Weinberg; Dale P Sandler; Jack A Taylor
Journal:  J Natl Cancer Inst       Date:  2013-04-11       Impact factor: 13.506

10.  Effects of age, sex, and persistent organic pollutants on DNA methylation in children.

Authors:  Karen Huen; Paul Yousefi; Asa Bradman; Liying Yan; Kim G Harley; Katherine Kogut; Brenda Eskenazi; Nina Holland
Journal:  Environ Mol Mutagen       Date:  2013-12-26       Impact factor: 3.216
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