| Literature DB >> 20927470 |
Daniel J Kleinbaum1, Eric T Kool.
Abstract
Fluorescence-quenched nucleic acid probes with reactive moieties at both the 5' and 3' ends are synthesized and tested for reaction with two adjacent nucleophile-containing DNAs. These probes improve signal to background over singly reactive probes and can discriminate single nucleotide polymorphisms in the target DNA or RNA.Entities:
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Year: 2010 PMID: 20927470 PMCID: PMC5504956 DOI: 10.1039/c0cc01968b
Source DB: PubMed Journal: Chem Commun (Camb) ISSN: 1359-7345 Impact factor: 6.222