Mikhail N Koffarnus1, Jonathan L Katz. 1. Department of Psychiatry, Johns Hopkins University School of Medicine, 5200 Eastern Ave., Suite 142W, Baltimore, MD 21224, USA. mkoffar1@jhmi.edu
Abstract
RATIONALE: Increased signal-detection accuracy on the 5-choice serial reaction time (5-CSRT) task has been shown with drugs that are useful clinically in treating attention deficit hyperactivity disorder (ADHD), but these increases are often small and/or unreliable. By reducing the reinforcer frequency, it may be possible to increase the sensitivity of this task to pharmacologically induced improvements in accuracy. METHODS: Rats were trained to respond on the 5-CSRT task on a fixed ratio (FR) 1, FR 3, or FR 10 schedule of reinforcement. Drugs that were and were not expected to enhance performance were then administered before experimental sessions. RESULTS: Significant increases in accuracy of signal detection were not typically obtained under the FR 1 schedule with any drug. However, d-amphetamine, methylphenidate, and nicotine typically increased accuracy under the FR 3 and FR 10 schedules. CONCLUSIONS: Increasing the FR requirement in the 5-CSRT task increases the likelihood of a positive result with clinically effective drugs, and may more closely resemble conditions in children with attention deficits.
RATIONALE: Increased signal-detection accuracy on the 5-choice serial reaction time (5-CSRT) task has been shown with drugs that are useful clinically in treating attention deficit hyperactivity disorder (ADHD), but these increases are often small and/or unreliable. By reducing the reinforcer frequency, it may be possible to increase the sensitivity of this task to pharmacologically induced improvements in accuracy. METHODS:Rats were trained to respond on the 5-CSRT task on a fixed ratio (FR) 1, FR 3, or FR 10 schedule of reinforcement. Drugs that were and were not expected to enhance performance were then administered before experimental sessions. RESULTS: Significant increases in accuracy of signal detection were not typically obtained under the FR 1 schedule with any drug. However, d-amphetamine, methylphenidate, and nicotine typically increased accuracy under the FR 3 and FR 10 schedules. CONCLUSIONS: Increasing the FR requirement in the 5-CSRT task increases the likelihood of a positive result with clinically effective drugs, and may more closely resemble conditions in children with attention deficits.
Authors: E D Levin; C K Conners; D Silva; S C Hinton; W H Meck; J March; J E Rose Journal: Psychopharmacology (Berl) Date: 1998-11 Impact factor: 4.530
Authors: E D Levin; C K Conners; E Sparrow; S C Hinton; D Erhardt; W H Meck; J E Rose; J March Journal: Psychopharmacology (Berl) Date: 1996-01 Impact factor: 4.530
Authors: Joachim Hauser; Andreas Reissmann; Thomas-A Sontag; Oliver Tucha; Klaus W Lange Journal: J Neural Transm (Vienna) Date: 2017-01-21 Impact factor: 3.575