Literature DB >> 20924402

The molecular principles of N-end rule recognition.

Shashikanth M Sriram1, Yong Tae Kwon.   

Abstract

The N-end rule pathway is a proteolytic system in which recognition components (N-recognins) recognize a set of N-terminal residues as part of degradation signals (N-degrons). Two studies in this issue report the structures of Ubr boxes, a substrate recognition domain of eukaryotic N-recognins. We discuss how eukaryotic and prokaryotic N-recognins use a similar molecular principle to recognize a different set of N-degrons.

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Year:  2010        PMID： 20924402     DOI： 10.1038/nsmb1010-1164

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  25 in total

1.  An essential role of N-terminal arginylation in cardiovascular development.

Authors:  Yong Tae Kwon; Anna S Kashina; Ilia V Davydov; Rong-Gui Hu; Jee Young An; Jai Wha Seo; Fangyong Du; Alexander Varshavsky
Journal:  Science       Date:  2002-07-05       Impact factor: 47.728

2.  ClpS is an essential component of the N-end rule pathway in Escherichia coli.

Authors:  A Erbse; R Schmidt; T Bornemann; J Schneider-Mergener; A Mogk; R Zahn; D A Dougan; B Bukau
Journal:  Nature       Date:  2006-02-09       Impact factor: 49.962

3.  N-terminal acetylation of cellular proteins creates specific degradation signals.

Authors:  Cheol-Sang Hwang; Anna Shemorry; Alexander Varshavsky
Journal:  Science       Date:  2010-01-28       Impact factor: 47.728

4.  Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases.

Authors:  Woo Suk Choi; Byung-Cheon Jeong; Yoo Jin Joo; Myeong-Ryeol Lee; Joon Kim; Michael J Eck; Hyun Kyu Song
Journal:  Nat Struct Mol Biol       Date:  2010-09-12       Impact factor: 15.369

5.  A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

Authors:  Takafumi Tasaki; Lubbertus C F Mulder; Akihiro Iwamatsu; Min Jae Lee; Ilia V Davydov; Alexander Varshavsky; Mark Muesing; Yong Tae Kwon
Journal:  Mol Cell Biol       Date:  2005-08       Impact factor: 4.272

6.  Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome).

Authors:  Martin Zenker; Julia Mayerle; Markus M Lerch; Andreas Tagariello; Klaus Zerres; Peter R Durie; Matthias Beier; Georg Hülskamp; Celina Guzman; Helga Rehder; Frits A Beemer; Ben Hamel; Philippe Vanlieferinghen; Ruth Gershoni-Baruch; Marta W Vieira; Miroslav Dumic; Ron Auslender; Vera L Gil-da-Silva-Lopes; Simone Steinlicht; Manfred Rauh; Stavit A Shalev; Christian Thiel; Arif B Ekici; Andreas Winterpacht; Yong Tae Kwon; Alexander Varshavsky; André Reis
Journal:  Nat Genet       Date:  2005-11-20       Impact factor: 38.330

7.  Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.

Authors:  Takafumi Tasaki; Reinhard Sohr; Zanxian Xia; Rainer Hellweg; Heide Hörtnagl; Alexander Varshavsky; Yong Tae Kwon
Journal:  J Biol Chem       Date:  2007-04-26       Impact factor: 5.157

8.  The mouse and human genes encoding the recognition component of the N-end rule pathway.

Authors:  Y T Kwon; Y Reiss; V A Fried; A Hershko; J K Yoon; D K Gonda; P Sangan; N G Copeland; N A Jenkins; A Varshavsky
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-07       Impact factor: 11.205

Review 9.  Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway.

Authors:  Shashikanth M Sriram; Rajkumar Banerjee; Ravi S Kane; Yong Tae Kwon
Journal:  Chem Biol       Date:  2009-02-27

10.  The substrate recognition domains of the N-end rule pathway.

Authors:  Takafumi Tasaki; Adriana Zakrzewska; Drew D Dudgeon; Yonghua Jiang; John S Lazo; Yong Tae Kwon
Journal:  J Biol Chem       Date:  2008-11-13       Impact factor: 5.157
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  26 in total

Review 1.  The N-end rule pathway: emerging functions and molecular principles of substrate recognition.

Authors:  Shashikanth M Sriram; Bo Yeon Kim; Yong Tae Kwon
Journal:  Nat Rev Mol Cell Biol       Date:  2011-10-21       Impact factor: 94.444

2.  Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes.

Authors:  Min Jae Lee; Dong Eun Kim; Adriana Zakrzewska; Young Dong Yoo; Su-Hyeon Kim; Sung Tae Kim; Jai Wha Seo; Young Sook Lee; Gerald W Dorn; Uhtaek Oh; Bo Yeon Kim; Yong Tae Kwon
Journal:  J Biol Chem       Date:  2012-05-10       Impact factor: 5.157

3.  Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

Authors:  Peter C W Lee; Mathew E Sowa; Steven P Gygi; J Wade Harper
Journal:  Mol Cell       Date:  2011-08-05       Impact factor: 17.970

Review 4.  The N-end rule pathway and regulation by proteolysis.

Authors:  Alexander Varshavsky
Journal:  Protein Sci       Date:  2011-08       Impact factor: 6.725

5.  Function of RAD6B and RNF8 in spermatogenesis.

Authors:  Yingli Guo; Yanfeng Song; Zhao Guo; Mengjin Hu; Bing Liu; Hongyu Duan; Le Wang; Tianxia Yuan; Degui Wang
Journal:  Cell Cycle       Date:  2018-01-19       Impact factor: 4.534

6.  PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5.

Authors:  Dae-Hee Lee; Daeho Kim; Sung Tae Kim; Soyeon Jeong; Jung Lim Kim; Sang Mi Shim; Ah Jung Heo; Xinxin Song; Zong Sheng Guo; David L Bartlett; Sang Cheul Oh; Junho Lee; Yoshiro Saito; Bo Yeon Kim; Yong Tae Kwon; Yong J Lee
Journal:  Autophagy       Date:  2018-07-23       Impact factor: 16.016

7.  Glioma-derived cancer stem cells are hypersensitive to proteasomal inhibition.

Authors:  Young Dong Yoo; Dae-Hee Lee; Hyunjoo Cha-Molstad; Hyungsin Kim; Su Ran Mun; Changhoon Ji; Seong Hye Park; Ki Sa Sung; Seung Ah Choi; Joonsung Hwang; Deric M Park; Seung-Ki Kim; Kyung-Jae Park; Shin-Hyuk Kang; Sang Cheul Oh; Aaron Ciechanover; Yong J Lee; Bo Yeon Kim; Yong Tae Kwon
Journal:  EMBO Rep       Date:  2016-12-19       Impact factor: 8.807

Review 8.  The N-end rule pathway.

Authors:  Takafumi Tasaki; Shashikanth M Sriram; Kyong Soo Park; Yong Tae Kwon
Journal:  Annu Rev Biochem       Date:  2012-04-10       Impact factor: 23.643

9.  Production and quantification of sesquiterpenes in Saccharomyces cerevisiae, including extraction, detection and quantification of terpene products and key related metabolites.

Authors:  Sarah Rodriguez; James Kirby; Charles M Denby; Jay D Keasling
Journal:  Nat Protoc       Date:  2014-07-24       Impact factor: 13.491

10.  Downregulation of the Arg/N-degron Pathway Sensitizes Cancer Cells to Chemotherapy In Vivo.

Authors:  Dominique Leboeuf; Tatiana Abakumova; Tatiana Prikazchikova; Luke Rhym; Daniel G Anderson; Timofei S Zatsepin; Konstantin I Piatkov
Journal:  Mol Ther       Date:  2020-01-21       Impact factor: 11.454
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