Literature DB >> 20922726

Reductive dehydroxylation of allyl alcohols by IspH protein.

Tobias Gräwert1, Ingrid Span, Adelbert Bacher, Michael Groll.   

Abstract

The biosynthesis of natural products is a treasure trove of unusual reaction mechanisms. This Minireview summarizes recent work on the structure and mechanism of IspH protein, which catalyzes the reductive dehydroxylation of an allyl alcohol in a biosynthetic pathway leading to isoprenoid precursors.

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Year:  2010        PMID： 20922726     DOI： 10.1002/anie.201000833

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  17 in total

1.  A closer look at the spectroscopic properties of possible reaction intermediates in wild-type and mutant (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase.

Authors:  Weiya Xu; Nicholas S Lees; Dominique Hall; Dhanushi Welideniya; Brian M Hoffman; Evert C Duin
Journal:  Biochemistry       Date:  2012-06-07       Impact factor: 3.162

2.  Challenges and Hallmarks of Establishing Alkylacetylphosphonates as Probes of Bacterial 1-Deoxy-d-xylulose 5-Phosphate Synthase.

Authors:  Sara Sanders; Ryan J Vierling; David Bartee; Alicia A DeColli; Mackenzie J Harrison; Joseph L Aklinski; Andrew T Koppisch; Caren L Freel Meyers
Journal:  ACS Infect Dis       Date:  2017-06-21       Impact factor: 5.084

3.  Biosynthesis of isoprene units: Mössbauer spectroscopy of substrate and inhibitor binding to the [4Fe-4S] cluster of the LytB/IspH enzyme.

Authors:  Annegret Ahrens-Botzong; Karnjapan Janthawornpong; Juliusz A Wolny; Erasmienne Ngouamegne Tambou; Michel Rohmer; Sergiy Krasutsky; C Dale Poulter; Volker Schünemann; Myriam Seemann
Journal:  Angew Chem Int Ed Engl       Date:  2011-10-19       Impact factor: 15.336

4.  Study of IspH, a key enzyme in the methylerythritol phosphate pathway using fluoro-substituted substrate analogues.

Authors:  Youli Xiao; Wei-chen Chang; Hung-wen Liu; Pinghua Liu
Journal:  Org Lett       Date:  2011-10-07       Impact factor: 6.005

5.  Inhibition Studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes.

Authors:  Jérôme de Ruyck; Johan Wouters; C Dale Poulter
Journal:  Curr Enzym Inhib       Date:  2011-07

Review 6.  Terpene biosynthesis: modularity rules.

Authors:  Eric Oldfield; Fu-Yang Lin
Journal:  Angew Chem Int Ed Engl       Date:  2011-11-21       Impact factor: 15.336

Review 7.  Biochemistry of the non-mevalonate isoprenoid pathway.

Authors:  Tobias Gräwert; Michael Groll; Felix Rohdich; Adelbert Bacher; Wolfgang Eisenreich
Journal:  Cell Mol Life Sci       Date:  2011-07-09       Impact factor: 9.261

8.  Mechanistic binding insights for 1-deoxy-D-Xylulose-5-Phosphate synthase, the enzyme catalyzing the first reaction of isoprenoid biosynthesis in the malaria-causing protists, Plasmodium falciparum and Plasmodium vivax.

Authors:  Matthew R Battistini; Christopher Shoji; Sumit Handa; Leonid Breydo; David J Merkler
Journal:  Protein Expr Purif       Date:  2015-12-15       Impact factor: 1.650

Review 9.  Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis.

Authors:  Weixue Wang; Eric Oldfield
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-31       Impact factor: 15.336

10.  Inhibition of IspH, a [4Fe-4S]2+ enzyme involved in the biosynthesis of isoprenoids via the methylerythritol phosphate pathway.

Authors:  Karnjapan Janthawornpong; Sergiy Krasutsky; Philippe Chaignon; Michel Rohmer; C Dale Poulter; Myriam Seemann
Journal:  J Am Chem Soc       Date:  2013-01-29       Impact factor: 15.419
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