Literature DB >> 20921414

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity.

Marian Beekman1, Christa Nederstigt, H Eka D Suchiman, Dennis Kremer, Ruud van der Breggen, Nico Lakenberg, Wendimagegn Ghidey Alemayehu, Anton J M de Craen, Rudi G J Westendorp, Dorret I Boomsma, Eco J C de Geus, Jeanine J Houwing-Duistermaat, Bastiaan T Heijmans, P Eline Slagboom.   

Abstract

A set of currently known alleles increasing the risk for coronary artery disease, cancer, and type 2 diabetes as identified by genome-wide association studies was tested for compatibility with human longevity. Here, we show that nonagenarian siblings from long-lived families and singletons older than 85 y of age from the general population carry the same number of disease risk alleles as young controls. Longevity in this study population is not compromised by the cumulative effect of this set of risk alleles for common disease.

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Year:  2010        PMID： 20921414      PMCID： PMC2964208          DOI： 10.1073/pnas.1003540107

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  30 in total

1.  Life-long sustained mortality advantage of siblings of centenarians.

Authors:  Thomas T Perls; John Wilmoth; Robin Levenson; Maureen Drinkwater; Melissa Cohen; Hazel Bogan; Erin Joyce; Stephanie Brewster; Louis Kunkel; Annibale Puca
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

2.  Cardiovascular advantages among the offspring of centenarians.

Authors:  Dellara F Terry; Marsha Wilcox; Maegan A McCormick; Elizabeth Lawler; Thomas T Perls
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2003-05       Impact factor: 6.053

3.  Performance of common genetic variants in breast-cancer risk models.

Authors:  Sholom Wacholder; Patricia Hartge; Ross Prentice; Montserrat Garcia-Closas; Heather Spencer Feigelson; W Ryan Diver; Michael J Thun; David G Cox; Susan E Hankinson; Peter Kraft; Bernard Rosner; Christine D Berg; Louise A Brinton; Jolanta Lissowska; Mark E Sherman; Rowan Chlebowski; Charles Kooperberg; Rebecca D Jackson; Dennis W Buckman; Peter Hui; Ruth Pfeiffer; Kevin B Jacobs; Gilles D Thomas; Robert N Hoover; Mitchell H Gail; Stephen J Chanock; David J Hunter
Journal:  N Engl J Med       Date:  2010-03-18       Impact factor: 91.245

4.  Identifying interacting SNPs using Monte Carlo logic regression.

Authors:  Charles Kooperberg; Ingo Ruczinski
Journal:  Genet Epidemiol       Date:  2005-02       Impact factor: 2.135

5.  Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.

Authors:  Manja Schoenmaker; Anton J M de Craen; Paul H E M de Meijer; Marian Beekman; Gerard J Blauw; P Eline Slagboom; Rudi G J Westendorp
Journal:  Eur J Hum Genet       Date:  2006-01       Impact factor: 4.246

Review 6.  Common gene variants, mortality and extreme longevity in humans.

Authors:  B T Heijmans; R G Westendorp; P E Slagboom
Journal:  Exp Gerontol       Date:  2000-09       Impact factor: 4.032

7.  Disability in the oldest old: "can do" or "do do"?

Authors:  A Bootsma-van der Wiel; J Gussekloo; A J de Craen; E van Exel; D L Knook; A M Lagaay; R G Westendorp
Journal:  J Am Geriatr Soc       Date:  2001-07       Impact factor: 5.562

8.  Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism.

Authors:  Stefan Kammerer; Lora L Burns-Hamuro; Yuliang Ma; Sara C Hamon; Jaume M Canaves; Michael M Shi; Matthew R Nelson; Charles F Sing; Charles R Cantor; Susan S Taylor; Andreas Braun
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-19       Impact factor: 11.205

9.  Lower all-cause, cardiovascular, and cancer mortality in centenarians' offspring.

Authors:  Dellara F Terry; Marsha A Wilcox; Maegan A McCormick; JaeMi Y Pennington; Emily A Schoenhofen; Stacy L Andersen; Thomas T Perls
Journal:  J Am Geriatr Soc       Date:  2004-12       Impact factor: 5.562

10.  Cardiovascular disease delay in centenarian offspring.

Authors:  Dellara F Terry; Marsha A Wilcox; Maegan A McCormick; Thomas T Perls
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-04       Impact factor: 6.053
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  76 in total

1.  Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Authors:  Mette Soerensen; Serena Dato; Qihua Tan; Mikael Thinggaard; Rabea Kleindorp; Marian Beekman; Rune Jacobsen; H Eka D Suchiman; Anton J M de Craen; Rudi G J Westendorp; Stefan Schreiber; Tinna Stevnsner; Vilhelm A Bohr; P Eline Slagboom; Almut Nebel; James W Vaupel; Kaare Christensen; Matt McGue; Lene Christiansen
Journal:  Exp Gerontol       Date:  2012-03-03       Impact factor: 4.032

2.  Genomics of human health and aging.

Authors:  Alexander M Kulminski; Irina Culminskaya
Journal:  Age (Dordr)       Date:  2011-12-16

Review 3.  The place of genetics in ageing research.

Authors:  Nir Barzilai; Leonard Guarente; Thomas B L Kirkwood; Linda Partridge; Thomas A Rando; P Eline Slagboom
Journal:  Nat Rev Genet       Date:  2012-07-10       Impact factor: 53.242

Review 4.  Genome maintenance and human longevity.

Authors:  Miook Cho; Yousin Suh
Journal:  Curr Opin Genet Dev       Date:  2014-08-28       Impact factor: 5.578

5.  Lifestyle factors of people with exceptional longevity.

Authors:  Swapnil N Rajpathak; Yingheng Liu; Orit Ben-David; Saritha Reddy; Gil Atzmon; Jill Crandall; Nir Barzilai
Journal:  J Am Geriatr Soc       Date:  2011-08-03       Impact factor: 5.562

Review 6.  From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health.

Authors:  Jesse D Riordan; Joseph H Nadeau
Journal:  Am J Hum Genet       Date:  2017-08-03       Impact factor: 11.025

7.  Four Genome-Wide Association Studies Identify New Extreme Longevity Variants.

Authors:  Paola Sebastiani; Anastasia Gurinovich; Harold Bae; Stacy Andersen; Alberto Malovini; Gil Atzmon; Francesco Villa; Aldi T Kraja; Danny Ben-Avraham; Nir Barzilai; Annibale Puca; Thomas T Perls
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-10-12       Impact factor: 6.053

8.  Centenarians: Great expectations.

Authors:  Michael Eisenstein
Journal:  Nature       Date:  2012-12-06       Impact factor: 49.962

Review 9.  How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.

Authors:  Anatoliy I Yashin; Konstantin G Arbeev; Liubov S Arbeeva; Deqing Wu; Igor Akushevich; Mikhail Kovtun; Arseniy Yashkin; Alexander Kulminski; Irina Culminskaya; Eric Stallard; Miaozhu Li; Svetlana V Ukraintseva
Journal:  Biogerontology       Date:  2015-08-18       Impact factor: 4.277

10.  Associations between longevity of parents and glucose regulation in their offspring: the KORA S4/F4 Study.

Authors:  B Kowall; A Peters; B Thorand; W Rathmann; C Meisinger
Journal:  Diabetologia       Date:  2012-10-18       Impact factor: 10.122
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