Literature DB >> 20890934

Studies with Wnt genes and nonsyndromic cleft lip and palate.

Renato Menezes1, Ariadne Letra, Ana H Kim, Erika C Küchler, Alicia Day, Patricia N Tannure, Luise Gomes da Motta, Katiucia B S Paiva, Jose M Granjeiro, Alexandre R Vieira.   

Abstract

BACKGROUND: Clefts of the lip and/or palate (cleft lip/palate) are notable for their complex etiology. The WNT pathway regulates multiple developmental processes including craniofacial development and may play a role in cleft lip/palate and other defects of craniofacial development such as tooth agenesis. Variations in WNT genes have been recently associated with cleft lip/palate in humans. In addition, two WNT genes, Wnt3 and Wnt9B, are located in the clf1 cleft locus in mice.
METHODS: We investigated 13 SNPs located in Wnt3A, Wnt5A, Wnt8A, Wnt11, Wnt3, and Wnt9B genes for association with cleft lip/palate subphenotypes in 463 cleft cases and 303 unrelated controls. Genotyping of selected polymorphisms was carried out using Taqman assays. PLINK 1.06 software was used to test for differences in allele frequencies of each polymorphism between affected and unaffected individuals. Haplotype analysis was also performed.
RESULTS: Individuals carrying variant alleles in WNT3 presented an increased risk for cleft lip/palate (p = 0.0003; OR, 1.61; 95% CI, 1.29-2.02) in the population studied.
CONCLUSION: Our results continue to support a role for WNT genes in the pathogenesis of cleft lip/palate. Although much remains to be learned about the function of individual WNT genes during craniofacial development, additional studies should focus on the identification of potentially functional variants in these genes as contributors to human clefting. Birth Defects Research (Part A), 2010. © 2010 Wiley-Liss, Inc.
Copyright © 2010 Wiley-Liss, Inc.

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Year:  2010        PMID： 20890934      PMCID： PMC2991560          DOI： 10.1002/bdra.20720

Source DB:  PubMed          Journal:  Birth Defects Res A Clin Mol Teratol        ISSN： 1542-0752


  18 in total

1.  Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.

Authors:  Thomas J Carroll; Joo-Seop Park; Shigemi Hayashi; Arindam Majumdar; Andrew P McMahon
Journal:  Dev Cell       Date:  2005-08       Impact factor: 12.270

2.  Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.

Authors:  Anita Woods; Guoyan Wang; Holly Dupuis; Zhuhong Shao; Frank Beier
Journal:  J Biol Chem       Date:  2007-06-14       Impact factor: 5.157

3.  PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors:  Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal:  Am J Hum Genet       Date:  2007-07-25       Impact factor: 11.025

4.  Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test.

Authors:  Diana M Juriloff; Muriel J Harris; Andrew P McMahon; Thomas J Carroll; Andrew C Lidral
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2006-08

Review 5.  Gene/environment causes of cleft lip and/or palate.

Authors:  J C Murray
Journal:  Clin Genet       Date:  2002-04       Impact factor: 4.438

6.  Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice.

Authors:  Diana M Juriloff; Muriel J Harris; Sarah L Dewell; Carolyn J Brown; Dixie L Mager; Liane Gagnier; Diana G Mah
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2005-02

7.  Differential Shh, Bmp and Wnt gene expressions during craniofacial development in mice.

Authors:  Katiucia Batista Silva Paiva; Maria das Graças Silva-Valenzuela; Silvia Maria Gomes Massironi; Gui Mi Ko; Filipe Modolo Siqueira; Fabio Daumas Nunes
Journal:  Acta Histochem       Date:  2009-07-15       Impact factor: 2.479

8.  A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci.

Authors:  Diana M Juriloff; Muriel J Harris; Sarah L Dewell
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2004-08

9.  Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.

Authors:  Yu Lan; Rosemary C Ryan; Zunyi Zhang; Steven A Bullard; Jeffrey O Bush; Kathleen M Maltby; Andrew C Lidral; Rulang Jiang
Journal:  Dev Dyn       Date:  2006-05       Impact factor: 3.780

10.  Homozygous WNT3 mutation causes tetra-amelia in a large consanguineous family.

Authors:  Stephan Niemann; Chengfeng Zhao; Filon Pascu; Ulrich Stahl; Ute Aulepp; Lee Niswander; James L Weber; Ulrich Müller
Journal:  Am J Hum Genet       Date:  2004-02-05       Impact factor: 11.025
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  34 in total

1.  Toward Microsurgical Correction of Cleft Lip Ex Utero through Restoration of Craniofacial Developmental Programs.

Authors:  Xue Dong; Wilmina N Landford; James Hart; Maurizio Risolino; Omer Kaymakcalan; Julia Jin; Yoshiko Toyoda; Elisabetta Ferretti; Licia Selleri; Jason A Spector
Journal:  Plast Reconstr Surg       Date:  2017-07       Impact factor: 4.730

2.  Further evidence of association of the ABCA4 gene with cleft lip/palate.

Authors:  Clarissa Fontoura; Renato M Silva; Jose M Granjeiro; Ariadne Letra
Journal:  Eur J Oral Sci       Date:  2012-10-15       Impact factor: 2.612

3.  Association of AXIN2 with non-syndromic oral clefts in multiple populations.

Authors:  A Letra; B Bjork; M E Cooper; H Szabo-Rogers; F W B Deleyiannis; L L Field; A E Czeizel; L Ma; G P Garlet; F A Poletta; J C Mereb; J S Lopez-Camelo; E E Castilla; I M Orioli; S Wendell; S H Blanton; K Liu; J T Hecht; M L Marazita; A R Vieira; R M Silva
Journal:  J Dent Res       Date:  2012-02-27       Impact factor: 6.116

4.  Computational gene expression modeling identifies salivary biomarker analysis that predict oral feeding readiness in the newborn.

Authors:  Jill L Maron; Jooyeon S Hwang; Subash Pathak; Robin Ruthazer; Ruby L Russell; Gil Alterovitz
Journal:  J Pediatr       Date:  2015-02       Impact factor: 4.406

5.  Modulating Wnt Signaling Rescues Palate Morphogenesis in Pax9 Mutant Mice.

Authors:  C Li; Y Lan; R Krumlauf; R Jiang
Journal:  J Dent Res       Date:  2017-07-10       Impact factor: 6.116

6.  Craniofacial abnormalities and altered wnt and mmp mRNA expression in zebrafish embryos exposed to gasoline oxygenates ETBE and TAME.

Authors:  Josephine A Bonventre; Lori A White; Keith R Cooper
Journal:  Aquat Toxicol       Date:  2012-04-25       Impact factor: 4.964

7.  Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development.

Authors:  Yong-Ri Jin; Xiang Hua Han; Makoto M Taketo; Jeong Kyo Yoon
Journal:  Development       Date:  2012-03-29       Impact factor: 6.868

8.  Frizzled 2 and frizzled 7 function redundantly in convergent extension and closure of the ventricular septum and palate: evidence for a network of interacting genes.

Authors:  Huimin Yu; Xin Ye; Nini Guo; Jeremy Nathans
Journal:  Development       Date:  2012-10-24       Impact factor: 6.868

9.  Association of WNT9B Gene Polymorphisms With Nonsyndromic Cleft Lip With or Without Cleft Palate in Brazilian Nuclear Families.

Authors:  Clarissa Fontoura; Renato M Silva; José M Granjeiro; Ariadne Letra
Journal:  Cleft Palate Craniofac J       Date:  2015-01

10.  Down-regulation of Wnt10a by RNA interference inhibits proliferation and promotes apoptosis in mouse embryonic palatal mesenchymal cells through Wnt/β-catenin signaling pathway.

Authors:  Cuijuan Feng; Zhongfei Xu; Zengjian Li; Dan Zhang; Qiang Liu; Li Lu
Journal:  J Physiol Biochem       Date:  2013-05-28       Impact factor: 4.158
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