| Literature DB >> 20890809 |
Chun Whan Choi1, Yeon Hee Choi, Mi-Ran Cha, Young Sup Kim, Gyu Hwan Yon, Kyung Sik Hong, Woo-Kyu Park, Young Ho Kim, Shi Yong Ryu.
Abstract
A new resveratrol oligomer (1) together with eight related components (2- 9) were isolated from the seed extract of Paeonia lactiflora (Paeoniaceae) as active principles responsible for the inhibition of beta-site APP-cleaving enzyme 1 (BACE-1) in vitro. The chemical structure of 1 was established as (-)-7a,8a- CIS- ε-viniferin with the aid of spectroscopic analyses including NOESY experiments. All isolated resveratrol oligomers (1- 9) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed by the FRET assay using Rh-EVNLDAEFK as a substrate in vitro. © Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2010 PMID： 20890809 DOI： 10.1055/s-0030-1250370
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352