| Literature DB >> 20888359 |
Swagata Das1, Biswajit Mishra, Kamaldeep Gill, Md Saquib Ashraf, Abhay Kumar Singh, Mou Sinha, Sujata Sharma, Immaculata Xess, Krishna Dalal, Tej Pal Singh, Sharmistha Dey.
Abstract
The Aloe protein of 14 kDa from the Aloe vera leaf gel was isolated by an ion exchange chromatography using DEAE-cellulose and CM-cellulose column. The purified Aloe protein exhibited a potent anti-fungal activity against Candida paraprilosis, Candida krusei and Candida albicans. In addition, the purified Aloe protein also showed an anti-inflammatory property against pure lipoxygenase and cyclooxygenase-2 with 84% and 73% inhibition, respectively, and was verified by binding with these proteins by real time method by the phenomenon of surface plasmon resonance. This Aloe protein is a novel protein possessing antifungal and anti-inflammatory properties and thus sets a platform to be used as a medicinal plant product.Entities:
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Year: 2010 PMID： 20888359 DOI： 10.1016/j.ijbiomac.2010.09.010
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953