Sumita Halder1, Ashish K Mehta, Pramod K Mediratta. 1. Department of Pharmacology, University College of Medical Sciences (University of Delhi), Delhi, India. sumitahalder123@rediffmail.com
Abstract
OBJECTIVE: The present study was performed to explore the effect of aqueous extract of Aloe vera on parameters of humoral and cell-mediated immunity. MATERIALS AND METHODS: Delayed-type hypersensitivity was assessed by measuring foot pad thickness following sensitisation by keyhole limpet haemocyanin injection and subsequently challenged by the same. Humoral immunity was assessed by measurement of haemagglutination titre to sheep red blood cells. RESULTS: Aloe vera (400 mg/kg, p.o.) produced a significant decrease in foot pad thickness compared with the control group, and also significantly enhanced the secondary humoral immune response. CONCLUSION: Thus, these findings suggest that A. vera can modulate immune response by augmenting secondary humoral immunity and decreasing cell-mediated immunity.
OBJECTIVE: The present study was performed to explore the effect of aqueous extract of Aloe vera on parameters of humoral and cell-mediated immunity. MATERIALS AND METHODS: Delayed-type hypersensitivity was assessed by measuring foot pad thickness following sensitisation by keyhole limpet haemocyanin injection and subsequently challenged by the same. Humoral immunity was assessed by measurement of haemagglutination titre to sheep red blood cells. RESULTS:Aloe vera (400 mg/kg, p.o.) produced a significant decrease in foot pad thickness compared with the control group, and also significantly enhanced the secondary humoral immune response. CONCLUSION: Thus, these findings suggest that A. vera can modulate immune response by augmenting secondary humoral immunity and decreasing cell-mediated immunity.
Authors: Gianandrea Guidetti; Alessandro Di Cerbo; Angela Giovazzino; Valentina Rubino; Anna Teresa Palatucci; Sara Centenaro; Elena Fraccaroli; Laura Cortese; Maria Grazia Bonomo; Giuseppina Ruggiero; Sergio Canello; Giuseppe Terrazzano Journal: J Immunol Res Date: 2016-08-15 Impact factor: 4.818
Authors: Laura Cortese; Mariangela Annunziatella; Anna Teresa Palatucci; Sarah Lanzilli; Valentina Rubino; Alessandro Di Cerbo; Sara Centenaro; Gianandrea Guidetti; Sergio Canello; Giuseppe Terrazzano Journal: BMC Vet Res Date: 2015-12-03 Impact factor: 2.741