| Literature DB >> 20888222 |
P Veeraraghavan Ramachandran1, Debarshi Pratihar, Hari Narayanan G Nair, Matthew Walters, Sadie Smith, Michele T Yip-Schneider, Huangbing Wu, C Max Schmidt.
Abstract
A selected series of racemic α-methylene-γ-butyrolactones (AMGBL) were synthesized via allylboration and screened against three human pancreatic cancer cell lines (Panc-1, MIA PaCa-2, and BxPC-3). This systematic study established a discernible relationship between the substitution pattern of AMGBL and their anti-proliferative activity. β,γ-diaryl-AMGBLs, particularly those with a trans-relationship exhibited higher potency than parthenolide and LC-1 against all three cell lines.Entities:
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Year: 2010 PMID： 20888222 DOI： 10.1016/j.bmcl.2010.09.022
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823