| Literature DB >> 20887888 |
Bulent Cetin1, Don W Cleveland.
Abstract
Aneuploidy, or an abnormal number of chromosomes, adversely affects cell growth, but it is also linked with cancer and tumorigenesis. Now, Torres et al. (2010) help to resolve this paradox by demonstrating that aneuploid yeast cells can evolve mutations in the proteasome protein degradation pathway that alleviate imbalances in protein production and increase the cell's proliferative capacities.Entities:
Year: 2010 PMID: 20887888 PMCID: PMC2955074 DOI: 10.1016/j.cell.2010.09.030
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582