BACKGROUND: The aim of the present study is to determine corneal physiology and endothelial morphology after proper image analysis technique in type I and II diabetic patients. The HbA1c level and the grade of retinopathy were also recorded and correlated with the endothelial parameters. METHODS: 41 eyes of 21 patients with type I and 59 eyes of 30 patients with type II diabetes mellitus (mean age was 40.97 ± 15.46 and 64.36 ± 10.47 years) were examined and compared to age-matched controls. Endothelial cell density (ECD), mean cell area, coefficient of variation of cell area, central corneal thickness, intraocular pressure, and grade of retinopathy were recorded. RESULTS: There was a statistically significant decreased endothelial cell density in type I disease (2428 ± 219 cell/mm2) in comparison with healthy subjects (2495 ± 191 cell/mm2, P=0.02). The diabetic corneas were thicker than normal (P=0.001). The HbA1c level was inversely correlated with the ECD (r=-0.60; P<0.0001) and correlated with the mean endothelial cell area (r=0.60, P<0.0001). Significant correlation was observed between the endothelial morphology and grade of diabetic retinopathy (r=-0.40, ECD; r=0.38, mean cell area; P=0.01 for both). In type II diabetes mellitus no significant difference was found in the evaluated values. CONCLUSIONS: The present study disclosed the alteration of the corneal endothelial morphology in type I diabetes mellitus as compared to normal subjects. The results indicated that type I diabetic corneas are more susceptible to environmental changes than type II corneas.
BACKGROUND: The aim of the present study is to determine corneal physiology and endothelial morphology after proper image analysis technique in type I and II diabeticpatients. The HbA1c level and the grade of retinopathy were also recorded and correlated with the endothelial parameters. METHODS: 41 eyes of 21 patients with type I and 59 eyes of 30 patients with type II diabetes mellitus (mean age was 40.97 ± 15.46 and 64.36 ± 10.47 years) were examined and compared to age-matched controls. Endothelial cell density (ECD), mean cell area, coefficient of variation of cell area, central corneal thickness, intraocular pressure, and grade of retinopathy were recorded. RESULTS: There was a statistically significant decreased endothelial cell density in type I disease (2428 ± 219 cell/mm2) in comparison with healthy subjects (2495 ± 191 cell/mm2, P=0.02). The diabetic corneas were thicker than normal (P=0.001). The HbA1c level was inversely correlated with the ECD (r=-0.60; P<0.0001) and correlated with the mean endothelial cell area (r=0.60, P<0.0001). Significant correlation was observed between the endothelial morphology and grade of diabetic retinopathy (r=-0.40, ECD; r=0.38, mean cell area; P=0.01 for both). In type II diabetes mellitus no significant difference was found in the evaluated values. CONCLUSIONS: The present study disclosed the alteration of the corneal endothelial morphology in type I diabetes mellitus as compared to normal subjects. The results indicated that type I diabetic corneas are more susceptible to environmental changes than type II corneas.
Authors: Jonathan H Lass; Tonya D Riddlesworth; Robin L Gal; Craig Kollman; Beth A Benetz; Francis W Price; Alan Sugar; Mark A Terry; Mark Soper; Roy W Beck Journal: Ophthalmology Date: 2014-11-15 Impact factor: 12.079
Authors: Ruchi Shah; Cynthia Amador; Kati Tormanen; Sean Ghiam; Mehrnoosh Saghizadeh; Vaithi Arumugaswami; Ashok Kumar; Andrei A Kramerov; Alexander V Ljubimov Journal: Exp Eye Res Date: 2021-01-21 Impact factor: 3.467
Authors: Jordan M Burnham; Monali Sakhalkar; Marlyn P Langford; Chanping Liang; Thomas B Redens; Sushil K Jain Journal: Clin Ophthalmol Date: 2013-01-10