Literature DB >> 20886301

2-methoxy-1,4-naphthoquinone isolated from Impatiens balsamina in a screening program for activity to inhibit Wnt signaling.

Naomi Mori1, Kazufumi Toume, Midori A Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi.   

Abstract

A screening study using a luciferase assay to identify natural products which inhibit Wnt signaling was carried out. The bioassay-guided fractionation of aerial parts of a plant, Impatiens balsamina, led to the isolation of 2-methoxy-1,4-naphthoquinone (1) as an active compound. Compound 1 inhibited the TCF/β-catenin (TOP) transcriptional activity (IC(50) 2.9 µM), while it decreased the transcriptional activity of FOP (mutated TCF-binding site)-transfected cells at >5 µM.

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Year:  2010        PMID： 20886301     DOI： 10.1007/s11418-010-0471-0

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  8 in total

Review 1.  Search for bioactive natural products from medicinal plants of Bangladesh.

Authors:  Firoj Ahmed; Samir Kumar Sadhu; Masami Ishibashi
Journal:  J Nat Med       Date:  2010-07-06       Impact factor: 2.343

2.  Determination of absolute stereochemistry, total synthesis, and evaluation of peptides from the myxomycete Physarum melleum.

Authors:  Shuwa Hanazawa; Midori A Arai; Xiaofan Li; Masami Ishibashi
Journal:  Bioorg Med Chem Lett       Date:  2007-11-05       Impact factor: 2.823

Review 3.  Mining the Wnt pathway for cancer therapeutics.

Authors:  Nick Barker; Hans Clevers
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

4.  A new coumestan from Tephrosia calophylla.

Authors:  Pennaka Hari Kishore; Mopuru Vijaya Bhaskar Reddy; Duvvuru Gunasekar; Madugula Marthanda Murthy; Cristelle Caux; Bernard Bodo
Journal:  Chem Pharm Bull (Tokyo)       Date:  2003-02       Impact factor: 1.645

5.  Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA).

Authors:  R Larsson; J Kristensen; C Sandberg; P Nygren
Journal:  Int J Cancer       Date:  1992-01-21       Impact factor: 7.396

6.  Antipruritic dinaphthofuran-7,12-dione derivatives from the pericarp of Impatiens balsamina.

Authors:  K Ishiguro; Y Ohira; H Oku
Journal:  J Nat Prod       Date:  1998-09       Impact factor: 4.050

7.  Synthesis, determination of stereochemistry, and evaluation of new bisindole alkaloids from the myxomycete Arcyria ferruginea: an approach for Wnt signal inhibitor.

Authors:  Kouken Kaniwa; Midori A Arai; Xiaofan Li; Masami Ishibashi
Journal:  Bioorg Med Chem Lett       Date:  2007-05-16       Impact factor: 2.823

8.  New Wnt/beta-catenin signaling inhibitors isolated from Eleutherine palmifolia.

Authors:  Xiaofan Li; Takashi Ohtsuki; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi
Journal:  Chem Asian J       Date:  2009-04-06
  8 in total
  5 in total

1.  β-Sitosterol and flavonoids isolated from Bauhinia malabarica found during screening for Wnt signaling inhibitory activity.

Authors:  Hyun Young Park; Kazufumi Toume; Midori A Arai; Takashi Koyano; Thaworn Kowithayakorn; Masami Ishibashi
Journal:  J Nat Med       Date:  2013-03-21       Impact factor: 2.343

Review 2.  Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials.

Authors:  Benjamin Lu; Brooke A Green; Jacqueline M Farr; Flávia C M Lopes; Terence J Van Raay
Journal:  Cancers (Basel)       Date:  2016-09-01       Impact factor: 6.639

3.  Adverse Effects of Hydroalcoholic Extracts and the Major Components in the Stems of Impatiens balsamina L. on Caenorhabditis elegans.

Authors:  Hong-Fang Jiang; Zi-Heng Zhuang; Bei-Wei Hou; Bao-Jun Shi; Cheng-Jie Shu; Lei Chen; Guo-Xin Shi; Wei-Ming Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2017-02-23       Impact factor: 2.629

Review 4.  Screening for natural products that affect Wnt signaling activity.

Authors:  Masami Ishibashi
Journal:  J Nat Med       Date:  2019-05-30       Impact factor: 2.343

5.  2-Methoxy-1,4-naphthoquinone (MNQ) regulates cancer key genes of MAPK, PI3K, and NF-κB pathways in Raji cells.

Authors:  Teck Yew Wong; Subramaniam Menaga; Chi-Ying F Huang; Siong Hock Anthony Ho; Seng Chiew Gan; Yang Mooi Lim
Journal:  Genomics Inform       Date:  2022-03-31
  5 in total

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