Literature DB >> 20882600

Mini review: protein-protein interactions in transcription: a fertile ground for helix mimetics.

Danielle A Guarracino1, Brooke N Bullock, Paramjit S Arora.   

Abstract

Designed ligands that inhibit protein-protein interactions involved in gene expression are valuable as reagents for genomics research and as leads for drug discovery efforts. Selective modulation of protein-protein interactions has proven to be a daunting task for synthetic ligands; however, the last decade has seen significant advances in inhibitor design, especially for helical protein interfaces. This review discusses examples of transcriptional complexes targeted by designer helices. 2010 Wiley Periodicals, Inc.

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Year:  2011        PMID： 20882600      PMCID： PMC2966508          DOI： 10.1002/bip.21546

Source DB:  PubMed          Journal:  Biopolymers        ISSN： 0006-3525            Impact factor:   2.505


  86 in total

Review 1.  Notch signaling as a therapeutic target.

Authors:  Yunsun Nam; Jon C Aster; Stephen C Blacklow
Journal:  Curr Opin Chem Biol       Date:  2002-08       Impact factor: 8.822

Review 2.  Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

Authors:  Michelle R Arkin; James A Wells
Journal:  Nat Rev Drug Discov       Date:  2004-04       Impact factor: 84.694

Review 3.  Peptide nucleic acid: a versatile tool in genetic diagnostics and molecular biology.

Authors:  P E Nielsen
Journal:  Curr Opin Biotechnol       Date:  2001-02       Impact factor: 9.740

4.  Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

Authors:  Deyun Wang; Wei Liao; Paramjit S Arora
Journal:  Angew Chem Int Ed Engl       Date:  2005-10-14       Impact factor: 15.336

5.  Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.

Authors:  W Seth Horne; Lisa M Johnson; Thomas J Ketas; Per Johan Klasse; Min Lu; John P Moore; Samuel H Gellman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

6.  Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions.

Authors:  I Radhakrishnan; G C Pérez-Alvarado; D Parker; H J Dyson; M R Montminy; P E Wright
Journal:  Cell       Date:  1997-12-12       Impact factor: 41.582

7.  Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Authors:  Yunsun Nam; Piotr Sliz; Luyan Song; Jon C Aster; Stephen C Blacklow
Journal:  Cell       Date:  2006-03-10       Impact factor: 41.582

8.  Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction.

Authors:  Jeffrey P Plante; Thomas Burnley; Barbora Malkova; Michael E Webb; Stuart L Warriner; Thomas A Edwards; Andrew J Wilson
Journal:  Chem Commun (Camb)       Date:  2009-06-24       Impact factor: 6.222

9.  Beta-peptidic peptidomimetics.

Authors:  Dieter Seebach; James Gardiner
Journal:  Acc Chem Res       Date:  2008-06-26       Impact factor: 22.384

10.  Synthesis, biological activity and conformational analysis of cyclic GRF analogs.

Authors:  A M Felix; E P Heimer; C T Wang; T J Lambros; A Fournier; T F Mowles; S Maines; R M Campbell; B B Wegrzynski; V Toome
Journal:  Int J Pept Protein Res       Date:  1988-12
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  7 in total

1.  Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach.

Authors:  Xiang Li; Emily A Foley; Shigehiro A Kawashima; Kelly R Molloy; Yinyin Li; Brian T Chait; Tarun M Kapoor
Journal:  Protein Sci       Date:  2013-01-27       Impact factor: 6.725

2.  Evaluation of diverse α/β-backbone patterns for functional α-helix mimicry: analogues of the Bim BH3 domain.

Authors:  Melissa D Boersma; Holly S Haase; Kimberly J Peterson-Kaufman; Erinna F Lee; Oliver B Clarke; Peter M Colman; Brian J Smith; W Seth Horne; W Douglas Fairlie; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2011-12-08       Impact factor: 15.419

3.  Small molecule probes to target the human Mediator complex.

Authors:  Andrew J Phillips; Dylan J Taatjes
Journal:  Isr J Chem       Date:  2013-08       Impact factor: 3.333

4.  Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1.

Authors:  Tara Rao; Gloria Ruiz-Gómez; Timothy A Hill; Huy N Hoang; David P Fairlie; Jody M Mason
Journal:  PLoS One       Date:  2013-03-27       Impact factor: 3.240

Review 5.  Hydrocarbon-stapled peptides: principles, practice, and progress.

Authors:  Loren D Walensky; Gregory H Bird
Journal:  J Med Chem       Date:  2014-03-06       Impact factor: 7.446

6.  OGlcNAcylation and phosphorylation have similar structural effects in α-helices: post-translational modifications as inducible start and stop signals in α-helices, with greater structural effects on threonine modification.

Authors:  Michael B Elbaum; Neal J Zondlo
Journal:  Biochemistry       Date:  2014-04-03       Impact factor: 3.162

7.  A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/β-catenin signalling pathway.

Authors:  Ye Wu; Ye-Hua Li; Xiang Li; Yan Zou; Hong-Li Liao; Lei Liu; Ye-Guang Chen; Donald Bierer; Hong-Gang Hu
Journal:  Chem Sci       Date:  2017-08-29       Impact factor: 9.825
  7 in total

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