BACKGROUND: Propofol is widely used for pediatric sedation. However, increasing depth of propofol sedation is associated with airway narrowing and obstruction. The aim of this study was to objectively assess airway patency during a low-dose propofol-based sedation regimen by measuring upper airway size and configuration with magnetic resonance imaging (MRI) in spontaneously breathing infants and children. METHODS: Magnetic resonance images of the upper airway were obtained in 138 infants and children, aged up to 6 years. Cross-sectional area, anteroposterior dimension, and transverse dimension were measured at the level of the soft palate, the base of the tongue, and the tip of the epiglottis. Sedation was induced with i.v. midazolam 0.1 mg·kg(-1) , nalbuphine 0.1 mg·kg(-1) , and propofol 1 mg·kg(-1) and maintained with propofol 5 mg·kg(-1) ·h(-1) . RESULTS: Median (IQR) age was 36 (15, 48) months, and mean body weight was 13.7 ± 5.6 kg. Airway patency was maintained in all infants and children. The narrowest part of the pharyngeal airway was measured at the level of the base of the tongue. Anteroposterior dimensions were narrower than transverse dimensions in all age groups at all measurement sites. Transverse dimensions increased with age at all measurement sites, while anteroposterior dimensions did not increase comparably. No patient demonstrated respiratory or cardiovascular adverse events. All MRI were completed successfully without sedation failure. CONCLUSION: Airway patency was maintained in all infants and children sedated with this low-dose propofol-based sedation regimen.
BACKGROUND:Propofol is widely used for pediatric sedation. However, increasing depth of propofol sedation is associated with airway narrowing and obstruction. The aim of this study was to objectively assess airway patency during a low-dose propofol-based sedation regimen by measuring upper airway size and configuration with magnetic resonance imaging (MRI) in spontaneously breathing infants and children. METHODS: Magnetic resonance images of the upper airway were obtained in 138 infants and children, aged up to 6 years. Cross-sectional area, anteroposterior dimension, and transverse dimension were measured at the level of the soft palate, the base of the tongue, and the tip of the epiglottis. Sedation was induced with i.v. midazolam 0.1 mg·kg(-1) , nalbuphine 0.1 mg·kg(-1) , and propofol 1 mg·kg(-1) and maintained with propofol 5 mg·kg(-1) ·h(-1) . RESULTS: Median (IQR) age was 36 (15, 48) months, and mean body weight was 13.7 ± 5.6 kg. Airway patency was maintained in all infants and children. The narrowest part of the pharyngeal airway was measured at the level of the base of the tongue. Anteroposterior dimensions were narrower than transverse dimensions in all age groups at all measurement sites. Transverse dimensions increased with age at all measurement sites, while anteroposterior dimensions did not increase comparably. No patient demonstrated respiratory or cardiovascular adverse events. All MRI were completed successfully without sedation failure. CONCLUSION: Airway patency was maintained in all infants and children sedated with this low-dose propofol-based sedation regimen.
Authors: Patrick K Munywoki; Dorothy C Koech; Charles N Agoti; Clement Lewa; Patricia A Cane; Graham F Medley; D J Nokes Journal: J Infect Dis Date: 2013-12-23 Impact factor: 5.226
Authors: Ying Ji Chuang; Seong Jae Hwang; Kevin A Buhr; Courtney A Miller; Gregory D Avey; Brad H Story; Houri K Vorperian Journal: PLoS One Date: 2022-03-11 Impact factor: 3.240