[Megaprostheses: KMFTR to GMRS].

The first trend-setting development of megaprostheses was initiated by Martin Salzer who introduced a ceramic prosthesis system in Vienna in 1972 for proximal humeral resection in patients with sarcoma and Ewing's sarcoma. Up until 1982, custom-made prostheses for the distal but also for the proximal femur were used for cementless implants with stem and side plates with screws. The Howmedica Modular Resection System (HMRS) exists since 1988. At the same time as the HMRS system was developed for the lower extremity, a system was also devised for the upper extremity, the Howmedica Humerus Modular Resection System, and the Global Modular Replacement System (GMRS) has been available since 2002.