Literature DB >> 20859658

Application of alpha7 nicotinic acetylcholine receptor agonists in inflammatory diseases: an overview.

Mario B Marrero1, Merouane Bencherif, Patrick M Lippiello, Rudolf Lucas.   

Abstract

Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as atherosclerosis, Crohn's, Alzheimer's and diabetes. Numerous cytokines play a significant role in this process, though tumor necrosis factor (TNF) and various interleukins are thought to be among the most important regulators. These proinflammatory cytokines promote the above-described diseases by inducing endothelial cell dysfunction. In this brief commentary we will discuss some of the latest advances and discoveries in the treatment of these inflammatory diseases, making use of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists.

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Year:  2010        PMID： 20859658     DOI： 10.1007/s11095-010-0283-7

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  10 in total

Review 1.  Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance.

Authors:  Jerry J Buccafusco; Sharon R Letchworth; Merouane Bencherif; Patrick M Lippiello
Journal:  Trends Pharmacol Sci       Date:  2005-07       Impact factor: 14.819

2.  Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB.

Authors:  Mario B Marrero; Merouane Bencherif
Journal:  Brain Res       Date:  2008-11-27       Impact factor: 3.252

3.  Activation of the cholinergic anti-inflammatory pathway reduces NF-kappab activation, blunts TNF-alpha production, and protects againts splanchic artery occlusion shock.

Authors:  Domenica Altavilla; Salvatore Guarini; Alessandra Bitto; Chiara Mioni; Daniela Giuliani; Albertino Bigiani; Giovanni Squadrito; Letteria Minutoli; Francesco S Venuti; Francesco Messineo; Vincenzo De Meo; Carla Bazzani; Francesco Squadrito
Journal:  Shock       Date:  2006-05       Impact factor: 3.454

4.  Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid.

Authors:  Seán Shaw; Merouane Bencherif; Mario B Marrero
Journal:  J Biol Chem       Date:  2002-09-18       Impact factor: 5.157

5.  Effect of nicotine on advanced glycation end product-induced immune response in human monocytes.

Authors:  Hideo Kohka Takahashi; Keyue Liu; Hidenori Wake; Shuji Mori; Jiyong Zhang; Rui Liu; Tadashi Yoshino; Masahiro Nishibori
Journal:  J Pharmacol Exp Ther       Date:  2009-12-02       Impact factor: 4.030

6.  Angiotensin II blocks nicotine-mediated neuroprotection against beta-amyloid (1-42) via activation of the tyrosine phosphatase SHP-1.

Authors:  Seán Shaw; Merouane Bencherif; Mario B Marrero
Journal:  J Neurosci       Date:  2003-12-03       Impact factor: 6.167

7.  Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.

Authors:  Xiao Su; Michael A Matthay; Asrar B Malik
Journal:  J Immunol       Date:  2009-11-30       Impact factor: 5.422

8.  An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes.

Authors:  Mario B Marrero; Rudolf Lucas; Christina Salet; Terry A Hauser; Anatoly Mazurov; Patrick M Lippiello; Merouane Bencherif
Journal:  J Pharmacol Exp Ther       Date:  2009-09-28       Impact factor: 4.030

9.  Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation.

Authors:  Hong Wang; Man Yu; Mahendar Ochani; Carol Ann Amella; Mahira Tanovic; Seenu Susarla; Jian Hua Li; Haichao Wang; Huan Yang; Luis Ulloa; Yousef Al-Abed; Christopher J Czura; Kevin J Tracey
Journal:  Nature       Date:  2002-12-22       Impact factor: 49.962

10.  Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation.

Authors:  Rubina W Saeed; Santosh Varma; Tina Peng-Nemeroff; Barbara Sherry; David Balakhaneh; Jared Huston; Kevin J Tracey; Yousef Al-Abed; Christine N Metz
Journal:  J Exp Med       Date:  2005-04-04       Impact factor: 14.307
  10 in total
  20 in total

1.  α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats.

Authors:  Kamil Duris; Anatol Manaenko; Hidenori Suzuki; William B Rolland; Paul R Krafft; John H Zhang
Journal:  Stroke       Date:  2011-09-29       Impact factor: 7.914

2.  α7nAChR is expressed in satellite cells at different myogenic status during skeletal muscle wound healing in rats.

Authors:  Zhi-Ling Tian; Shu-Kun Jiang; Miao Zhang; Meng Wang; Jiao-Yong Li; Rui Zhao; Lin-Lin Wang; Min Liu; Shan-Shan Li; Meng-Zhou Zhang; Da-Wei Guan
Journal:  J Mol Histol       Date:  2015-12       Impact factor: 2.611

3.  [(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR.

Authors:  Yongjun Gao; Ronnie C Mease; Thao T Olson; Kenneth J Kellar; Robert F Dannals; Martin G Pomper; Andrew G Horti
Journal:  Nucl Med Biol       Date:  2014-12-20       Impact factor: 2.408

4.  α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage.

Authors:  Paul R Krafft; Orhan Altay; William B Rolland; Kamil Duris; Tim Lekic; Jiping Tang; John H Zhang
Journal:  Stroke       Date:  2011-12-29       Impact factor: 7.914

5.  5-(5-(6-[(11)C]methyl-3,6-diazabicyclo[3.2.0]heptan-3-yl)pyridin-2-yl)-1H-indole as a potential PET radioligand for imaging cerebral α7-nAChR in mice.

Authors:  Yongjun Gao; Hayden T Ravert; Heather Valentine; Ursula Scheffel; Paige Finley; Dean F Wong; Robert F Dannals; Andrew G Horti
Journal:  Bioorg Med Chem       Date:  2012-05-04       Impact factor: 3.641

6.  Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.

Authors:  Miao-Wu Dong; Ming Li; Jie Chen; Tong-Tong Fu; Ke-Zhi Lin; Guang-Hua Ye; Jun-Ge Han; Xiang-Ping Feng; Xing-Biao Li; Lin-Sheng Yu; Yan-Yan Fan
Journal:  Inflammation       Date:  2016-04       Impact factor: 4.092

7.  The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.

Authors:  Kelen Freitas; F Ivy Carroll; M Imad Damaj
Journal:  J Pharmacol Exp Ther       Date:  2012-10-31       Impact factor: 4.030

8.  Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy.

Authors:  Chong-Hui Li; Xuan Zhang; Xin-Lan Ge; Xin Huang; Ai-Qun Zhang; Wan-Qing Gu
Journal:  Biomed Res Int       Date:  2014-11-12       Impact factor: 3.411

9.  Evidence for a prosurvival role of alpha-7 nicotinic acetylcholine receptor in alternatively (M2)-activated macrophages.

Authors:  Robert H Lee; Guillermo Vazquez
Journal:  Physiol Rep       Date:  2013-12-26

10.  MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines.

Authors:  Yang Sun; Qi Li; Huan Gui; Dong-Ping Xu; Yi-Li Yang; Ding-Feng Su; Xia Liu
Journal:  Cell Res       Date:  2013-08-27       Impact factor: 25.617
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