Literature DB >> 25687449

[(125)I]Iodo-ASEM, a specific in vivo radioligand for α7-nAChR.

Yongjun Gao1, Ronnie C Mease1, Thao T Olson2, Kenneth J Kellar2, Robert F Dannals1, Martin G Pomper1, Andrew G Horti3.   

Abstract

[(125)I]Iodo-ASEM, a new radioligand with high affinity and selectivity for α7-nAChRs (K(i) = 0.5 nM; α7/α4β2 = 3414), has been synthesized in radiochemical yield of 33 ± 6% from the corresponding di-butyltriazene derivative and at high specific radioactivity (1600Ci/mmol; 59.2 MBq/μmol). [(125)I]Iodo-ASEM readily entered the brains of normal CD-1 mice and specifically and selectively labeled cerebral α7-nAChRs. [(125)I]iodo-ASEM is a new useful tool for studying α7-nAChR.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Nicotinic acetylcholine receptor; SPECT; iodo-ASEM; α7-nAChR

Mesh：

Substances：

Year:  2014        PMID： 25687449      PMCID： PMC4387010          DOI： 10.1016/j.nucmedbio.2014.12.008

Source DB:  PubMed          Journal:  Nucl Med Biol        ISSN： 0969-8051            Impact factor:   2.408


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