BACKGROUND: The development of valid parent-report measures of symptom change in pediatric bipolar disorder (PBD) is imperative to evaluate the effectiveness of different treatment approaches; yet, few studies have tested the sensitivity of symptom measures. The current study evaluated the sensitivity of the Child Mania Rating Scale (CMRS-P) to detect symptom change over time in a treatment study for PBD. METHODS: Data on symptom change were drawn from a prospective six-week, double-blind, placebo-controlled, randomized outpatient medication treatment trial of risperidone versus divalproex. The sample included 66 children with Bipolar type I disorder. Measures were administered every week for six weeks of treatment. RESULTS: The CMRS-P demonstrated statistically (p ≤ .05) and clinically significant change in symptom report from pre to post-test. Growth curve modeling indicated that the CMRS-P demonstrated overall similarity to the YMRS in the magnitude and trajectory of change over time. Finally, results indicate that the CMRS-P is able to detect response rates with moderate levels of agreement with other measures. LIMITATIONS: Limitations of this study include a relatively small sample size and uncertain generalizability beyond treatment trials. CONCLUSIONS: The CMRS-P is short, easy to administer, and represents parent's report of symptoms, all strengths which make it a compelling treatment outcome tool. This preliminary evidence of its validity as a treatment outcome measure makes it applicable in other research settings and suggests its potential use in clinical settings.
RCT Entities:
BACKGROUND: The development of valid parent-report measures of symptom change in pediatric bipolar disorder (PBD) is imperative to evaluate the effectiveness of different treatment approaches; yet, few studies have tested the sensitivity of symptom measures. The current study evaluated the sensitivity of the ChildMania Rating Scale (CMRS-P) to detect symptom change over time in a treatment study for PBD. METHODS: Data on symptom change were drawn from a prospective six-week, double-blind, placebo-controlled, randomized outpatient medication treatment trial of risperidone versus divalproex. The sample included 66 children with Bipolar type I disorder. Measures were administered every week for six weeks of treatment. RESULTS: The CMRS-P demonstrated statistically (p ≤ .05) and clinically significant change in symptom report from pre to post-test. Growth curve modeling indicated that the CMRS-P demonstrated overall similarity to the YMRS in the magnitude and trajectory of change over time. Finally, results indicate that the CMRS-P is able to detect response rates with moderate levels of agreement with other measures. LIMITATIONS: Limitations of this study include a relatively small sample size and uncertain generalizability beyond treatment trials. CONCLUSIONS: The CMRS-P is short, easy to administer, and represents parent's report of symptoms, all strengths which make it a compelling treatment outcome tool. This preliminary evidence of its validity as a treatment outcome measure makes it applicable in other research settings and suggests its potential use in clinical settings.
Authors: J Kaufman; B Birmaher; D Brent; U Rao; C Flynn; P Moreci; D Williamson; N Ryan Journal: J Am Acad Child Adolesc Psychiatry Date: 1997-07 Impact factor: 8.829
Authors: Barbara L Gracious; Eric A Youngstrom; Robert L Findling; Joseph R Calabrese Journal: J Am Acad Child Adolesc Psychiatry Date: 2002-11 Impact factor: 8.829
Authors: Mani N Pavuluri; David B Henry; Robert L Findling; Stephanie Parnes; Julie A Carbray; Tahseen Mohammed; Philip G Janicak; John A Sweeney Journal: Bipolar Disord Date: 2010-09 Impact factor: 6.744
Authors: M Tohen; T G Jacobs; S L Grundy; S L McElroy; M C Banov; P G Janicak; T Sanger; R Risser; F Zhang; V Toma; J Francis; G D Tollefson; A Breier Journal: Arch Gen Psychiatry Date: 2000-09
Authors: Mani N Pavuluri; David B Henry; Bhargavi Devineni; Julie A Carbray; Boris Birmaher Journal: J Am Acad Child Adolesc Psychiatry Date: 2006-05 Impact factor: 8.829
Authors: Rinad S Beidas; Rebecca E Stewart; Lucia Walsh; Steven Lucas; Margaret Mary Downey; Kamilah Jackson; Tara Fernandez; David S Mandell Journal: Cogn Behav Pract Date: 2015-02-01
Authors: Amy E West; Sally M Weinstein; Amy T Peters; Andrea C Katz; David B Henry; Rick A Cruz; Mani N Pavuluri Journal: J Am Acad Child Adolesc Psychiatry Date: 2014-09-08 Impact factor: 8.829
Authors: Sally M Weinstein; David B Henry; Andrea C Katz; Amy T Peters; Amy E West Journal: J Am Acad Child Adolesc Psychiatry Date: 2014-11-22 Impact factor: 8.829
Authors: Eric Youngstrom; Joan Zhao; Raymond Mankoski; Robert A Forbes; Ronald M Marcus; William Carson; Robert McQuade; Robert L Findling Journal: J Child Adolesc Psychopharmacol Date: 2013-03-12 Impact factor: 2.576
Authors: Benjamin I Goldstein; Boris Birmaher; Gabrielle A Carlson; Melissa P DelBello; Robert L Findling; Mary Fristad; Robert A Kowatch; David J Miklowitz; Fabiano G Nery; Guillermo Perez-Algorta; Anna Van Meter; Cristian P Zeni; Christoph U Correll; Hyo-Won Kim; Janet Wozniak; Kiki D Chang; Manon Hillegers; Eric A Youngstrom Journal: Bipolar Disord Date: 2017-09-25 Impact factor: 6.744
Authors: Daniel J Walker; Melissa P DelBello; John Landry; Deborah N D'Souza; Holland C Detke Journal: Child Adolesc Psychiatry Ment Health Date: 2017-07-12 Impact factor: 3.033