| Literature DB >> 20856952 |
Anass Znabet1, Marloes M Polak, Elwin Janssen, Frans J J de Kanter, Nicholas J Turner, Romano V A Orru, Eelco Ruijter.
Abstract
A very short and efficient synthesis of the important drug candidate telaprevir, featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps, is presented. The classical issue of lack of stereoselectivity in Ugi- and Passerini-type reactions is circumvented. The atom economic and convergent nature of the synthetic strategy require only very limited use of protective groups.Entities:
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Year: 2010 PMID： 20856952 DOI： 10.1039/c0cc02823a
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222