Literature DB >> 20854870

Recurrence of konzo in southern Tanzania: rehabilitation and prevention using the wetting method.

N L V Mlingi1, S Nkya, S R Tatala, S Rashid, J H Bradbury.   

Abstract

There have been four konzo outbreaks in Tanzania from 1985 to 2002/2003 with a total of 363 cases of konzo. Every outbreak of konzo resulted from large cyanogen intakes from bitter cassava during drought, which caused food shortages and led to people using short-cut methods of cassava processing. Rehabilitation of the 214 konzo subjects from the two most recent outbreaks of konzo in southern Tanzania was carried out by screening konzo subjects and included provision of crutches and wheel chairs. The wetting method was taught to 216 women activists from the konzo-prone villages, in the first large scale community based intervention to reduce cyanogen intake. Using cassava cyanide kits, the average total cyanide content was reduced by the wetting method about 4-fold, in agreement with previous studies. This model to help prevent konzo requires the widespread education of women activists to use the wetting method.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20854870     DOI: 10.1016/j.fct.2010.09.017

Source DB:  PubMed          Journal:  Food Chem Toxicol        ISSN: 0278-6915            Impact factor:   6.023


  15 in total

Review 1.  Konzo: a distinct neurological disease associated with food (cassava) cyanogenic poisoning.

Authors:  Espérance Kashala-Abotnes; Daniel Okitundu; Dieudonne Mumba; Michael J Boivin; Thorkild Tylleskär; Desire Tshala-Katumbay
Journal:  Brain Res Bull       Date:  2018-07-05       Impact factor: 4.077

2.  Determinants of cognitive performance in children relying on cyanogenic cassava as staple food.

Authors:  G M Bumoko; M T Sombo; L D Okitundu; D N Mumba; K T Kazadi; J J Tamfum-Muyembe; M R Lasarev; M J Boivin; J P Banea; D D Tshala-Katumbay
Journal:  Metab Brain Dis       Date:  2014-02-01       Impact factor: 3.584

3.  Lower serum levels of selenium, copper, and zinc are related to neuromotor impairments in children with konzo.

Authors:  G M-M Bumoko; N H Sadiki; A Rwatambuga; K P Kayembe; D L Okitundu; D Mumba Ngoyi; J-J T Muyembe; J-P Banea; M J Boivin; D Tshala-Katumbay
Journal:  J Neurol Sci       Date:  2015-01-10       Impact factor: 3.181

Review 4.  Cyanide and the human brain: perspectives from a model of food (cassava) poisoning.

Authors:  Desire D Tshala-Katumbay; Nadege N Ngombe; Daniel Okitundu; Larry David; Shawn K Westaway; Michael J Boivin; Ngoyi D Mumba; Jean-Pierre Banea
Journal:  Ann N Y Acad Sci       Date:  2016-07-23       Impact factor: 5.691

Review 5.  Konzo: from poverty, cassava, and cyanogen intake to toxico-nutritional neurological disease.

Authors:  Hipólito Nzwalo; Julie Cliff
Journal:  PLoS Negl Trop Dis       Date:  2011-06-28

6.  Health effects of drought: a systematic review of the evidence.

Authors:  Carla Stanke; Marko Kerac; Christel Prudhomme; Jolyon Medlock; Virginia Murray
Journal:  PLoS Curr       Date:  2013-06-05

7.  Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars.

Authors:  Olusegun Steven Ayodele Oluwole; Adeyinka Oludiran
Journal:  Int J Health Geogr       Date:  2013-09-14       Impact factor: 3.918

8.  Serum 8,12-iso-iPF2α-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo.

Authors:  Bumoko G Makila-Mabe; Kambale J Kikandau; Thérèse M Sombo; Daniel L Okitundu; Jean-Claude Mwanza; Michael J Boivin; Mumba D Ngoyi; Jean-Jacques T Muyembe; Jean-Pierre Banea; Gerard R Boss; Desiré Tshala-Katumbay
Journal:  PLoS One       Date:  2014-09-15       Impact factor: 3.240

Review 9.  A global perspective on the influence of environmental exposures on the nervous system.

Authors:  Desire Tshala-Katumbay; Jean-Claude Mwanza; Diane S Rohlman; Gladys Maestre; Reinaldo B Oriá
Journal:  Nature       Date:  2015-11-19       Impact factor: 49.962

10.  Effect of genotype and genotype by environment interaction on total cyanide content, fresh root, and starch yield in farmer-preferred cassava landraces in Tanzania.

Authors:  Mariam K Mtunguja; Henry S Laswai; Edward Kanju; Joseph Ndunguru; Yasinta C Muzanila
Journal:  Food Sci Nutr       Date:  2016-02-09       Impact factor: 2.863

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