Literature DB >> 20852791

Fluorinase mediated chemoenzymatic synthesis of [(18)F]-fluoroacetate.

Xiang-Guo Li1, Juozas Domarkas, David O'Hagan.   

Abstract

A novel preparation of sodium [(18)F]-fluoroacetate is described where 5'-[(18)F]-fluoro-5'-deoxyadenosine is generated by a fluorinase catalysed reaction of S-adenosyl-l-methionine (SAM) with no carrier added [(18)F]-fluoride and then oxidation to [(18)F]-fluoroacetate by a Kuhn-Roth oxidative degradation.

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Year:  2010        PMID： 20852791     DOI： 10.1039/c0cc02264k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

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Journal:  F1000Res       Date:  2014-02-19

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Journal:  Front Bioeng Biotechnol       Date:  2022-08-17
  4 in total

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