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Literature DB >> 20852771

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.

P Matthew Joyner¹, Jinman Liu, Zhijun Zhang, Justin Merritt, Fengxia Qi, Robert H Cichewicz.

Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2010 PMID： 20852771 PMCID： PMC2992086 DOI： 10.1039/c0ob00579g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

16 in total

1. Chemical sensing in mammalian host-bacterial commensal associations.

Authors: David T Hughes; Darya A Terekhova; Linda Liou; Carolyn J Hovde; Jason W Sahl; Arati V Patankar; Juan E Gonzalez; Thomas S Edrington; David A Rasko; Vanessa Sperandio
Journal: Proc Natl Acad Sci U S A Date: 2010-05-10 Impact factor: 11.205

2. Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism.

Authors: Laila P Partida-Martinez; Shamci Monajembashi; Karl-Otto Greulich; Christian Hertweck
Journal: Curr Biol Date: 2007-04-05 Impact factor: 10.834

3. Strategies for the discovery of new natural products by genome mining.

Authors: Malek Zerikly; Gregory L Challis
Journal: Chembiochem Date: 2009-03-02 Impact factor: 3.164

Review 4. Intercellular communication in bacteria.

Authors: L Caetano M Antunes; Rosana B R Ferreira
Journal: Crit Rev Microbiol Date: 2009 Impact factor: 7.624

5. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.

Authors: Volker Schroeckh; Kirstin Scherlach; Hans-Wilhelm Nützmann; Ekaterina Shelest; Wolfgang Schmidt-Heck; Julia Schuemann; Karin Martin; Christian Hertweck; Axel A Brakhage
Journal: Proc Natl Acad Sci U S A Date: 2009-08-06 Impact factor: 11.205

6. Streptococcus mutans competence-stimulating peptide inhibits Candida albicans hypha formation.

Authors: Lucja M Jarosz; Dong Mei Deng; Henny C van der Mei; Wim Crielaard; Bastiaan P Krom
Journal: Eukaryot Cell Date: 2009-08-28

Review 7. Inter-kingdom signaling: chemical language between bacteria and host.

Authors: Alline R Pacheco; Vanessa Sperandio
Journal: Curr Opin Microbiol Date: 2009-03-21 Impact factor: 7.934

Review 8. Inter-kingdom encounters: recent advances in molecular bacterium-fungus interactions.

Authors: Mika T Tarkka; Alain Sarniguet; Pascale Frey-Klett
Journal: Curr Genet Date: 2009-04-01 Impact factor: 3.886

Review 9. The microbes of the intestine: an introduction to their metabolic and signaling capabilities.

Authors: William W L Hsiao; Christine Metz; Davinder P Singh; Jesse Roth
Journal: Endocrinol Metab Clin North Am Date: 2008-12 Impact factor: 4.741

10. Translating metabolic exchange with imaging mass spectrometry.

Authors: Yu-Liang Yang; Yuquan Xu; Paul Straight; Pieter C Dorrestein
Journal: Nat Chem Biol Date: 2009-11-08 Impact factor: 15.040

47 in total

Review 1. Bacterial-fungal interactions: hyphens between agricultural, clinical, environmental, and food microbiologists.

Authors: P Frey-Klett; P Burlinson; A Deveau; M Barret; M Tarkka; A Sarniguet
Journal: Microbiol Mol Biol Rev Date: 2011-12 Impact factor: 11.056

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.

1. Chemical sensing in mammalian host-bacterial commensal associations.

2. Endosymbiont-dependent host reproduction maintains bacterial-fungal mutualism.

3. Strategies for the discovery of new natural products by genome mining.

Review 4. Intercellular communication in bacteria.

5. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.

6. Streptococcus mutans competence-stimulating peptide inhibits Candida albicans hypha formation.

Review 7. Inter-kingdom signaling: chemical language between bacteria and host.

Review 8. Inter-kingdom encounters: recent advances in molecular bacterium-fungus interactions.

Review 9. The microbes of the intestine: an introduction to their metabolic and signaling capabilities.

10. Translating metabolic exchange with imaging mass spectrometry.

Review 1. Bacterial-fungal interactions: hyphens between agricultural, clinical, environmental, and food microbiologists.

2. CovR alleviates transcriptional silencing by a nucleoid-associated histone-like protein in Streptococcus mutans.

Review 3. Signaling Natural Products from Human Pathogenic Bacteria.

Review 4. Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans.

5. From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms.

6. Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products.

Review 7. Natural products as mediators of disease.

8. Regulation of transcription by SMU.1349, a TetR family regulator, in Streptococcus mutans.

9. Design, synthesis, and biological evaluation of α-hydroxyacyl-AMS inhibitors of amino acid adenylation enzymes.

10. Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii.