| Literature DB >> 20850437 |
Eline Remue1, Kris Meerschaert, Tsutomu Oka, Ciska Boucherie, Joël Vandekerckhove, Marius Sudol, Jan Gettemans.
Abstract
The transcriptional coactivator TAZ recognizes L/PPxY motifs in transcription factors like Runx1/2 through its WW domain. We show that the first PDZ domain of zona occludens-1 (ZO-1) and 2 (ZO-2) interacts with the carboxy-terminal PDZ binding motif of TAZ. Deletion of this motif abrogates binding. ZO-2 colocalizes with TAZ in the nucleus of MDCK cells and ZO-2 expression alters TAZ localization in human embryonic kidney cells. Luciferase assays demonstrate ZO-2 inhibition of TAZ-mediated transactivation. We propose that zonula occludens is a negative regulator of TAZ and suggest that selected tight junction proteins control nuclear translocation and activity of TAZ.Entities:
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Year: 2010 PMID： 20850437 DOI： 10.1016/j.febslet.2010.09.020
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124