AIMS: To study the effect of in-utero alcohol exposure on the insulin-like growth factor axis (IGF) and leptin during infancy and childhood, considering that exposed children may exhibit pre- and postnatal growth retardation. METHODS: We prospectively identified heavily drinking pregnant women who consumed on average 4 or more drinks of ethanol per day (≥ 48 g/day) and assessed growth in 69 of their offspring and an unexposed control group of 83 children, measuring serum IGF-I (radioimmunoassay), IGF-II (immunoradiometric assay, IRMA), insulin-like growth factor-binding protein 3 (IGFBP-3) (IRMA) and leptin (IRMA) at 1 month and 1, 2, 3, 4, and 5 years of age. RESULTS: IGF-II levels increased with age in both groups, but the rate of increase was significantly higher in exposed children, and levels were significantly higher in ethanol-exposed children at 3, 4, and 5 years of age. In exposed children, IGF-I levels were higher at 3 and 4 years and leptin levels were significantly lower at 1 and 2 years. Exposed subjects showed a much lower correlation between IGF-I and growth parameters than unexposed subjects. CONCLUSION: Exposure to ethanol during pregnancy increases IGF-I and IGF-II and decreases leptin during early childhood. The increase in serum IGF-II concentrations in ethanol-exposed children suggests that this hormone should be explored as a potential marker for prenatal alcohol exposure.
AIMS: To study the effect of in-utero alcohol exposure on the insulin-like growth factor axis (IGF) and leptin during infancy and childhood, considering that exposed children may exhibit pre- and postnatal growth retardation. METHODS: We prospectively identified heavily drinking pregnant women who consumed on average 4 or more drinks of ethanol per day (≥ 48 g/day) and assessed growth in 69 of their offspring and an unexposed control group of 83 children, measuring serum IGF-I (radioimmunoassay), IGF-II (immunoradiometric assay, IRMA), insulin-like growth factor-binding protein 3 (IGFBP-3) (IRMA) and leptin (IRMA) at 1 month and 1, 2, 3, 4, and 5 years of age. RESULTS:IGF-II levels increased with age in both groups, but the rate of increase was significantly higher in exposed children, and levels were significantly higher in ethanol-exposed children at 3, 4, and 5 years of age. In exposed children, IGF-I levels were higher at 3 and 4 years and leptin levels were significantly lower at 1 and 2 years. Exposed subjects showed a much lower correlation between IGF-I and growth parameters than unexposed subjects. CONCLUSION: Exposure to ethanol during pregnancy increases IGF-I and IGF-II and decreases leptin during early childhood. The increase in serum IGF-II concentrations in ethanol-exposed children suggests that this hormone should be explored as a potential marker for prenatal alcohol exposure.
Authors: M J E Walenkamp; H J van der Kamp; A M Pereira; S G Kant; H A van Duyvenvoorde; M F Kruithof; M H Breuning; J A Romijn; M Karperien; J M Wit Journal: J Clin Endocrinol Metab Date: 2006-06-06 Impact factor: 5.958
Authors: M J E Walenkamp; M Karperien; A M Pereira; Y Hilhorst-Hofstee; J van Doorn; J W Chen; S Mohan; A Denley; B Forbes; H A van Duyvenvoorde; S W van Thiel; C A Sluimers; J J Bax; J A P M de Laat; M B Breuning; J A Romijn; J M Wit Journal: J Clin Endocrinol Metab Date: 2005-03-15 Impact factor: 5.958
Authors: Sofia Aros; James L Mills; Claudia Torres; Cecilia Henriquez; Ariel Fuentes; Teresa Capurro; Maria Mena; Mary Conley; Christopher Cox; Caroline Signore; Mark Klebanoff; Fernando Cassorla Journal: Subst Use Misuse Date: 2006 Impact factor: 2.164
Authors: J Kratzsch; C Schubring; B Stitzel; A Böttner; A Berthold; J Thiery; W Kiess Journal: J Clin Endocrinol Metab Date: 2005-01-25 Impact factor: 5.958
Authors: Marvin R Diaz; Cyndel C Vollmer; Paula A Zamudio-Bulcock; William Vollmer; Samantha L Blomquist; Russell A Morton; Julie C Everett; Agnieszka A Zurek; Jieying Yu; Beverley A Orser; C Fernando Valenzuela Journal: Neuropharmacology Date: 2013-12-04 Impact factor: 5.250