OBJECTIVE: To investigate predictors of circulating leptin in healthy full-term newborns and to explore the relationship with anthropometric variables, serum levels of adiponectin and the major components of the IGF system at birth. To explore whether leptin levels are regulated by breastfeeding vs. formula feeding. DESIGN: Observational cross-sectional study. PATIENTS: Three hundred and nineteen healthy full-term newborns delivered during 1999 in Athens, Greece. MEASUREMENTS: Anthropometric measurements, formula feeding information and blood samples were obtained. Leptin and adiponectin determinations were performed using a radioimmunoassay (RIA). RESULTS: Multivariate regression analyses showed that leptin levels were positively associated with female gender, newborn length, ponderal index and IGF-I levels, but not with adiponectin levels. Newborns who were fed exclusively with milk formulas had more than twice the leptin levels of those who were exclusively breastfed. CONCLUSIONS: Leptin levels are positively related to female gender and anthropometric characteristics of neonates but, contrary to studies in adults, are not correlated with adiponectin levels. We also found evidence that formula feeding imparts a considerable increase in leptin levels in newborns.
OBJECTIVE: To investigate predictors of circulating leptin in healthy full-term newborns and to explore the relationship with anthropometric variables, serum levels of adiponectin and the major components of the IGF system at birth. To explore whether leptin levels are regulated by breastfeeding vs. formula feeding. DESIGN: Observational cross-sectional study. PATIENTS: Three hundred and nineteen healthy full-term newborns delivered during 1999 in Athens, Greece. MEASUREMENTS: Anthropometric measurements, formula feeding information and blood samples were obtained. Leptin and adiponectin determinations were performed using a radioimmunoassay (RIA). RESULTS: Multivariate regression analyses showed that leptin levels were positively associated with female gender, newborn length, ponderal index and IGF-I levels, but not with adiponectin levels. Newborns who were fed exclusively with milk formulas had more than twice the leptin levels of those who were exclusively breastfed. CONCLUSIONS:Leptin levels are positively related to female gender and anthropometric characteristics of neonates but, contrary to studies in adults, are not correlated with adiponectin levels. We also found evidence that formula feeding imparts a considerable increase in leptin levels in newborns.
Authors: Linda A Marino-Ortega; Adiel Molina-Bello; Julio C Polanco-García; José F Muñoz-Valle; Aralia B Salgado-Bernabé; Iris P Guzmán-Guzmán; Isela Parra-Rojas Journal: Int J Clin Exp Med Date: 2015-07-15
Authors: Sofía Aros; James L Mills; Germán Iñiguez; Alejandra Avila; Mary R Conley; James Troendle; Christopher Cox; Fernando Cassorla Journal: Horm Res Paediatr Date: 2010-09-15 Impact factor: 2.852
Authors: Eleni Th Petridou; Theodoros N Sergentanis; Nick Dessypris; Iris T Vlachantoni; Sofia Tseleni-Balafouta; Apostolos Pourtsidis; Maria Moschovi; Sofia Polychronopoulou; Fani Athanasiadou-Piperopoulou; Maria Kalmanti; Christos S Mantzoros Journal: J Clin Oncol Date: 2009-09-08 Impact factor: 44.544
Authors: Anni Larnkjær; Ken K Ong; Emma M Carlsen; Katrine T Ejlerskov; Christian Mølgaard; Kim F Michaelsen Journal: Horm Res Paediatr Date: 2018-06-29 Impact factor: 2.852